Chronic myelocytic leukemia with two Philadelphia chromosomes and prominent peripheral lymphadenopathy.
Chronic myelocytic leukemia with two Philadelphia chromosomes and prominent peripheral lymphadenopathy.
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具有两条费城染色体和明显外周淋巴结肿大的慢性粒细胞白血病。
DOI：
10.1182/blood.v29.4.652.652
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发表时间：
1967
期刊：
影响因子：
20.3
通讯作者：
S. Perry
中科院分区：
文献类型：
--
作者：
C. Duvall;P. Carbone;W. Bell;J. Whang;J. Tjio;S. Perry
(CML ).‘ Marked lymph node enlargement may occur late in the course of the disease, usually with the development of the myeloblast crisis, and may be considered a poor prognostic sign.2’3 Rarely, the clinical and histopathologic picture can mimic lymphoma.4 Recently, Kiossoglou, Mitus and Dameshek reported a patient with “significant” lymphadenopathy with hvo Philadelphia (Ph’ ) chromosomes.5 In reports of cytogenetic studies in CML there is no mention made of lymphadenopathy of marked degree in those patients with 2 Ph1 chromosomes.68 Three adult patients with chronic myelocytic leukemia, marked peripheral lymphadenopathy, and two Ph1 chromosomes are described in this report. It is noteworthy that all 3 patients had the double Ph’ chromosome in cytogenetic preparations and 2 of the 3 had significant adenopathy before blastic crisis occurred.
