Sesquiterpenoids and Benzofuranoids from the Marine-Derived Fungus Aspergillus ustus 094102
Sesquiterpenoids and Benzofuranoids from the Marine-Derived Fungus Aspergillus ustus 094102
复制标题
来自海洋源性真菌 Aspergillus ustus 的倍半萜类化合物和苯并呋喃类化合物 094102
DOI：
10.1021/np900268z
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发表时间：
2009-10-01
影响因子：
5.1
通讯作者：
Zhu, Weiming
中科院分区：
文献类型：
--
作者：
Lu, Zhenyu;Wang, Yi;Zhu, Weiming
从海洋来源的真菌Aspergillus ustus 094102的EtOAc提取物中分离出八种补身烷倍半萜烯（1-8）、六种异色烷衍生物（9-14）和三种已知化合物，daldinin B（15）、9 α-羟基-6 β-[（2 E，4 E，6 E）-辛-2，4，6-三烯酰氧基]-5 α-补身烷-7-烯-11，12-庚烯（16）和pergillin（17）。新化合物的结构经波谱分析鉴定。采用SRB法和MTT法检测其对A549和HL-60细胞的细胞毒作用。Ustusorane E（13）对HL-60细胞显示出显著的细胞毒性，IC 50值为0.13 μ M。Ustusolate C（6）和E（8）对A549和HL-60细胞表现出中等细胞毒性，IC 50值分别为10.5和9.0 μ M，Ustusolate A（4）对HL-60和A549细胞表现出弱细胞毒性，IC 50值分别为20.6和30.0 μ M。
Eight drimane sesquiterpenes (1-8), six isochromane derivatives (9-14), and three known compounds, daldinin B (15), 9 alpha-hydroxy-6 beta-[(2 E,4E,6E)-octa-2,4,6-trienoyloxy]-5 alpha-drim-7-en-11,12-olide (16), and pergillin (17), were isolated from the EtOAc extract of the marine-derived fungus Aspergillus ustus 094102. The structures of the new compounds were elucidated on the basis of spectroscopic analysis. The cytotoxic effects on A549 and HL-60 cell lines were evaluated by SRB and MTT methods. Ustusorane E (13) showed significant cytotoxicity against HL-60 cells with an IC50 value of 0.13 mu M. Ustusolates C (6) and E (8) exhibited moderate cytotoxicity against A549 and HL-60 cells with IC50 values of 10.5 and 9.0 mu M, respectively, and ustusolate A (4) showed weak cytotoxicity against HL-60 and A549 cells with IC50 values of 20.6 and 30.0 mu M, respectively.