LATERALIZED HUMAN BRAIN LANGUAGE SYSTEMS DEMONSTRATED BY TASK SUBTRACTION FUNCTIONAL MAGNETIC-RESONANCE-IMAGING
LATERALIZED HUMAN BRAIN LANGUAGE SYSTEMS DEMONSTRATED BY TASK SUBTRACTION FUNCTIONAL MAGNETIC-RESONANCE-IMAGING
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DOI：
10.1001/archneur.1995.00540300067015
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发表时间：
1995-06-01
影响因子：
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通讯作者：
HYDE, JS
中科院分区：
文献类型：
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作者：
BINDER, JR;RAO, SM;HYDE, JS
目的：建立一种功能磁共振成像（MRI）无创测量语言偏侧的方法。设计：使用时间序列回声平面MRI进行功能神经成像。环境：大学医学中心研究设施。实验对象：五个健康的右撇子年轻人。主要结果测量：在两个对比的听觉处理任务中，左半球和右半球显示任务相关信号的MRI体素数增加。非语言任务涉及纯音处理，而语言任务涉及基于语义内容的单个单词处理。结果：纯音加工任务激活了双侧颞叶听觉区和背外侧额叶区。以该任务为对照条件，语义处理任务导致左半球分布区域的偏侧活动。任务对脑内活动模式均有显著影响。结果在测试-重测信度的初步研究中得到了再现。结论：结果表明语义语言系统的侧化解剖与非语言听觉感觉处理器形成对比，并介绍了一种适用于功能MRI的任务减法技术，作为语言侧化的非侵入性测量。
Objective: To develop a procedure for noninvasive measurement of language lateralization with functional magnetic resonance imaging (MRI).Design: Functional neuroimaging using time-series echo-planar MRI.Setting: University medical center research facility.Subjects: Five healthy, right-handed, young adults.Main Outcome Measures: Number of MRI voxels in left and right hemispheres showing task-related signal increases during two contrasting auditory processing tasks. The nonlinguistic task involved processing of pure tones, while the linguistic task involved processing of single words based on semantic content.Results: The pure-tone processing task activated temporal lobe auditory areas and dorsolateral frontal regions bilaterally. Using this task as a control condition, the semantic processing task resulted in lateralized activity in distributed regions of the left hemisphere. A significant effect of task on intrahemispheric activity pattern was demonstrated in every subject. Results were reproduced in preliminary studies of test-retest reliability.Conclusions: The results demonstrate the lateralized anatomy of semantic linguistic systems in contrast to nonlinguistic auditory sensory processors and introduce a task subtraction technique adapted for functional MRI as a noninvasive measure of language lateralization.