Lifestyle correlates of plasma insulin-like growth factor I and insulin-like growth factor binding protein 3 concentrations.
Lifestyle correlates of plasma insulin-like growth factor I and insulin-like growth factor binding protein 3 concentrations.
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发表时间：
2002-09
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通讯作者：
M. Holmes;M. Pollak;S. Hankinson
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作者：
M. Holmes;M. Pollak;S. Hankinson
血浆胰岛素样生长因子I(IGF-I)水平与许多癌症和其他疾病的风险有关。我们对1037名健康女性的血浆IGF-I和IGF结合蛋白3(IGFBP-3)水平与年龄、吸烟、体力活动、生殖和更年期因素的横截面相关性进行了研究。通过线性回归计算不同生活方式因素的调整后最小二乘平均激素水平。年龄与IGF-I水平呈负相关。在多因素分析中，体重指数(BMI)越高，IGFBP-3水平越高(BMI=29 kg/m(2)，3879对4080 ng/ml；趋势P=0.01)。目前使用的激素替代疗法与较低的胰岛素样生长因子-I水平相关，口服雌激素与最低水平相关(未使用激素替代疗法与口服雌激素+孕酮与口服雌激素：181vs143vs116 ng/ml；所有比较的P=4：212vs180 ng/ml；趋势P=0.003)。我们得出结论，年龄和HRT的使用，特别是单用口服雌激素，与IGF-I水平呈负相关。BMI与IGFBP-3水平呈正相关。这是第一个循环中IGF-I水平与产次负相关的报告。这种联系可能代表了产次对某些癌症发挥保护作用的一种机制。
Plasma levels of insulin-like growth factor I (IGF-I) have been associated with risk of a number of cancers and other diseases. We examined the cross-sectional association of plasma IGF-I and IGF-binding protein 3 (IGFBP-3) levels with age, smoking, physical activity, and reproductive and menopausal factors in 1037 healthy women. Adjusted least-square mean hormone levels across categories of lifestyle factors were calculated by linear regression. Age was inversely associated with IGF-I levels. In multivariate analyses, a higher body mass index (BMI) was associated with higher IGFBP-3 levels (BMI /=29 kg/m(2), 3879 versus 4080 ng/ml; P for trend = 0.01). Current use of hormone replacement therapy (HRT) was associated with a lower IGF-I, with oral estrogen being associated with the lowest levels (non-use of HRT versus oral estrogen + progesterone versus oral estrogen: 181 versus 143 versus 116 ng/ml; P for all comparisons /=4: 212 versus 180 ng/ml; P for trend = 0.003). We conclude that age and HRT use, particularly oral estrogen alone, were inversely associated with IGF-I levels. BMI was positively associated with IGFBP-3 levels. This is the first report of an inverse association of circulating IGF-I levels with parity. This association may represent one mechanism by which parity exerts its protective effect on some cancers.