The HLA class I A locus affects susceptibility to type 1 diabetes
The HLA class I A locus affects susceptibility to type 1 diabetes
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DOI：
10.1016/s0198-8859(02)00421-4
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发表时间：
2002-08-01
期刊：
影响因子：
2.7
通讯作者：
Erlich, HA
中科院分区：
文献类型：
--
作者：
Noble, JA;Valdes, AM;Erlich, HA
采用固定化探针法对来自人类生物数据交换中心(HBDI)的283个多重、高加索、1型糖尿病家系样本进行了人类白细胞抗原A(HLA-A)基因分型。遗传给患者的HLAA等位基因的分布与家族性对照有显著差异(p=0.004)。传递不平衡检验(TDT)分析显示，几个HLA-A等位基因从双亲向受影响的后代传播存在差异。我们还对HLAII类基因座DRB1和DQB1进行了分型，从而可以将HLAA等位基因分配给单倍型，并计算连锁不平衡值。人类白细胞抗原A等位基因对1型糖尿病易感性的一些明显影响可归因于与DR和DQ等位基因的连锁不平衡，尽管其他的不是。等位基因A*0101、A*2402和A*3002在患者和对照组之间的频率差异不能仅用连锁不平衡来解释。我们的结果表明，I类抗原在调节1型糖尿病的易感性方面起着重要作用。(C)美国组织相容性和免疫遗传学会，2002年。爱思唯尔科学公司出版。
Human leukocyte antigen A (HLA-A) genotypes were determined for samples from 283 multiplex, Caucasian, type 1 diabetes families from the Human Biological Data Interchange (HBDI) using an immobilized probe assay. Distribution of HLA-A alleles transmitted to patients was significantly different from that in affected family-based controls (AFBAC) (p = 0.004). Transmission disequilibrium test (TDT) analysis revealed differential transmission of several HLA-A alleles from parents to affected offspring. HLA class II DRB1 and DQB1 loci were also typed, allowing assignment of HLA-A alleles to haplotypes and calculation of linkage disequilibrium values. Some of the apparent effects of HLA-A alleles on type 1 diabetes susceptibility were attributable to linkage disequilibrium with DR and DQ alleles, although others were not. The differences in frequencies between patients and controls of alleles A*0101, A*2402, and A*3002 could not be explained by linkage disequilibrium alone. Our results suggest an important role for class I antigens in modulating susceptibility to type 1 diabetes. (C) American Society for Histocompatibility and Immunogenetics, 2002. Published by Elsevier Science Inc.