Biological Importance and Applications of Squalene and Squalane
Biological Importance and Applications of Squalene and Squalane
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DOI：
10.1016/b978-0-12-416003-3.00014-7
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发表时间：
2012-01-01
期刊：
影响因子：
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通讯作者：
Karadeniz, Fatih
中科院分区：
文献类型：
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作者：
Kim, Se-Kwon;Karadeniz, Fatih
角鲨烯是一种多不饱和烃，分子式为C30H50。角鲨烯在某些鱼油中含量很高，尤其是鲨鱼肝油，而在某些植物油中含量相对较少。人类皮脂还含有 13% 的角鲨烯，是其主要成分之一。角鲨烷是角鲨烯的饱和衍生物，也存在于这些来源中。角鲨烯在鲨鱼肝油中的表征引起了人们的兴趣，鲨鱼肝油几十年来一直被用作传统药物。多项研究结果证明角鲨烯和角鲨烷具有某些生物活性。迄今为止，这些物质的抗癌、抗氧化、药物载体、解毒、皮肤保湿和润肤活性均已在动物模型和体外环境中得到报道。根据最近的研究结果，角鲨烯和角鲨烷被认为是实际和临床用途的重要物质，在营养保健品和制药行业具有巨大潜力。
Squalene is a polyunsaturated hydrocarbon with a formula of C30H50. Squalene can be found in certain fish oils, especially shark liver oil, in high amounts and some vegetable oils in relatively smaller amounts. Human sebum also contains 13% squalene as one of its major constituents. Squalane is a saturated derivative of squalene and also found in these sources. Interest in squalene has been raised after its characterization in shark liver oil which is used as a traditional medicine for decades. Several studies exhibited results that prove certain bioactivities for squalene and squalane. Up to date, anticancer, antioxidant, drug carrier, detoxifier, skin hydrating, and emollient activities of these substances have been reported both in animal models and in vitro environments. According to promising results from recent studies, squalene and squalane are considered important substances in practical and clinical uses with a huge potential in nutraceutical and pharmaceutical industries.