Effect of endothelin-1 on canine airway blood flow.
Effect of endothelin-1 on canine airway blood flow.
复制标题
内皮素-1对犬气道血流的影响。
DOI：
10.1097/00005344-199322008-00072
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发表时间：
1993
影响因子：
3
通讯作者：
Taylor,AE
中科院分区：
文献类型：
--
作者：
Barman,SA;Ardell,JL;Taylor,AE
通过分别向麻醉狗的右心和左心注射15μm放射性标记的微球，测量内皮素-1(ET-1)对肺循环和体循环对气管和主支气管的血流贡献的影响。注射微球后处死动物，切除气管软骨、气管肌粘膜和主支气管并收集用于放射性计数。这项研究的结果表明，在正常情况下，气管血流量主要是全身血流量（> 气管总血流量的 95%），平均为 25-50 ml/min/100 g，而肺循环（9-10 ml/min/100 g）和体循环（19-20 ml/min/100 g）对主支气管血流量有很大贡献。静脉注射ET-1使全身气管软骨血流量从25.3+/-3.8降低至14.5+/-2.8ml/min/100g，全身气管粘膜血流量从50.0+/-7.0降低至25.0+/-7.0ml/min/100g，全身主支气管血流量从19.4+/-4.6降低至11.6+/-3.4毫升/分钟/100 克（p < 0.05）。这些结果表明 ET-1 是气道循环的有效收缩剂，可能导致不同气道疾病状态下出现的气道缺血。
The effect of endothelin-1 (ET-1) on the blood flow contributions of the pulmonary and systemic circulations to the trachea and main bronchi were measured in anesthetized dogs by injecting 15-[mu] m radiolabeled microspheres into the right and left heart, respectively. After the microsphere injections the animals were killed, and the tracheal cartilage, tracheal muscle mucosa, and main bronchi were excised and collected for radioactive counting. The results of this study showed that under normal conditions tracheal blood flow was primarily systemic (> 95% of total tracheal blood flow) averaging 25-50 ml/min/100 g, whereas both the pulmonary (9-10 ml/min/100 g) and systemic circulations (19-20 ml/min/100 g) contributed substantially to main bronchi blood flow. Administration of ET-1 iv decreased systemic tracheal cartilage blood flow from 25.3+/-3.8 to 14.5+/-2.8 ml/min/100 g, systemic tracheal mucosal blood flow from 50.0+/-7.0 to 25.0+/-7.0 ml/min/100 g, and systemic main bronchi blood flow from 19.4+/-4.6 to 11.6+/-3.4 ml/min/100 g (p< 0.05). These results indicate that ET-1 is a potent constrictor of the airway circulation and may contribute to airway ischemia seen in different airway disease states.