Whisker experience modulates long-term depression in neocortical γ-aminobutyric acidergic interneurons in barrel cortex.
Whisker experience modulates long-term depression in neocortical γ-aminobutyric acidergic interneurons in barrel cortex.
复制标题
胡须经验调节桶状皮层新皮质γ-氨基丁酸能中间神经元的长期抑制。
DOI：
10.1002/jnr.22530
复制
发表时间：
2011
影响因子：
4.2
通讯作者：
Zhang,Zhi
中科院分区：
文献类型：
--
作者：
Sun,Qian-Quan;Zhang,Zhi
长期可塑性被认为是一种重要的机制，允许神经回路以使用依赖的方式进行调节。然而，关于感觉经验在调节新皮层GABA能中间神经元中的突触的长期可塑性中的作用的证据是不可用的。在这里，我们专注于规则尖峰非锥体（RSNP）中间神经元，并检查了尖峰配对诱导的突触可塑性及其通过离体感觉经验的调制。在我们以前的研究中，RSNP中间神经元没有表现出内在特性的经验依赖性可塑性或丘脑皮质（TC）突触的改变，并表现出mGluRs的强大调节。在这里，我们报告了桶皮质的RSNP中间神经元中的棘波配对诱导的长时程抑制（spLTD）。使用配对记录和丘脑诱导的反应，我们发现spLTD对皮质内突触而不是TC突触具有特异性。spLTD通过突触前mGluRs介导。的spLTD没有调制慢性或急性管理的NMDAR拮抗剂，但增强了感觉剥夺（通过胡须修剪）在出生后的敏感期离体。在RSNP细胞中，对皮质内神经元能突触特异性的spLTD突触及其通过感觉剥夺的调节可能有助于皮质回路的感觉依赖性重塑和沿着晶须相关柱的再分布回路活动。© 2010 Wiley利斯公司
Long‐term plasticity is believed to be an important mechanism that allows neural circuits to be modulated in an use‐dependent manner. However, evidence regarding the role of sensory experience in modulating long‐term plasticity of glutamatergic synapses in neocortical GABAergic interneurons is unavailable. Here, we focused on regular‐spiking nonpyramidal (RSNP) interneurons and examined spike‐pairing‐induced plasticity of glutamatergic synapses and its modulation by sensory experiences ex vivo. In our previous studies, RSNP interneurons do not show experience‐dependent plasticity of intrinsic properties or alteration of thalamocortical (TC) synapses and exhibit robust modulation by mGluRs. Here we report a spike‐pairing‐induced long‐term depression (spLTD) of glutamatergic synapses in RSNP interneurons of barrels cortex. Using paired recording and thalamic‐induced responses, we found that the spLTD was specific for intracortical but not TC synapses. The spLTD was mediated via presynaptic mGluRs. The spLTD was not modulated by chronic or acute administration of NMDAR antagonists but was enhanced by sensory deprivation (via whisker trimming) during a postnatal sensitive period ex vivo. The synapses specific spLTD to intracortical glutamatergic synapses in RSNP cells and their modulation by sensory deprivation may contribute to sensory‐dependent remodeling of cortical circuits and redistribution circuit activity along the whisker‐related columns. © 2010 Wiley‐Liss, Inc.
DNA修复：研究程序实验室手册
DOI：
--
发表时间：
1981
期刊：
影响因子：
--
作者：
E. Friedberg;P. Hanawalt
通讯作者：
P. Hanawalt
DNA 修复：研究程序实验室手册，1，A 部分。由 E. C. Friedberg 和 P. C. Hanawalt 编辑。
影响因子：
64.5
作者：
S. Shall
通讯作者：
S. Shall