Relationship Between Quality of Life and Survival in Patients With Pancreatic and Periampullary Cancer: A Multicenter Cohort Analysis
Relationship Between Quality of Life and Survival in Patients With Pancreatic and Periampullary Cancer: A Multicenter Cohort Analysis
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DOI：
10.6004/jnccn.2020.7579
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发表时间：
2020-10-01
影响因子：
13.4
通讯作者：
van Laarhoven, Hanneke W. M.
中科院分区：
文献类型：
--
作者：
Mackay, Tara M.;Latenstein, Anouk E. J.;van Laarhoven, Hanneke W. M.
背景资料：生活质量（QoL）和生存率之间的关系已被证明是几种类型的癌症，主要是在临床试验中高度选择的患者群体。胰腺癌或壶腹周围癌患者的生活质量与生存率之间的关系尚不清楚。研究方法：本研究分析了在荷兰全国癌症登记处（2015-2018年）登记的胰腺癌或壶腹周围癌患者的前瞻性多中心患者报告结局登记处的QoL数据。使用幸福感、EORTC生活质量量表-核心30（QLQ-C30）和QLQ-PAN 26问卷评估基线和基线与3个月随访之间的Δ QoL。使用考克斯回归模型评估生活质量和生存率之间的关系，使用Nagelkerke R-2（解释方差）评估单独项目的额外预后价值。结果：基线和delta分析分别有233例和148例患者可用。大多数被诊断为胰腺癌（n=194; 83.3%）和III期疾病（n=77; 33.0%），中位总生存期为13.6个月。使用基线评分的多变量分析表明，几个量表对整个队列具有预后价值（即，今天的幸福感、角色功能、腹泻、胰腺疼痛和身体形象;风险比均为P
Background: A relationship between quality of life (QoL) and survival has been shown for several types of cancer, mostly in clinical trials with highly selected patient groups. The relationship between QoL and survival for patients with pancreatic or periampullary cancer is unclear. Methods: This study analyzed QoL data from a prospective multicenter patient-reported outcome registry in patients with pancreatic or periampullary carcinoma registered in the nationwide Netherlands Cancer Registry (2015-2018). Baseline and delta QoL, between baseline and 3-month follow-up, were assessed with the Happiness, EORTC Quality of Life Questionnaire-Core 30 (QLQ-C30), and QLQ-PAN26 questionnaires. The relationship between QoL and survival was assessed using Cox regression models, and additional prognostic value of separate items was assessed using Nagelkerke R-2 (explained variance). Results: For the baseline and delta analyses, 233 and 148 patients were available, respectively. Most were diagnosed with pancreatic adenocarcinoma (n=194; 83.3%) and had stage III disease (n=77; 33.0%), with a median overall survival of 13.6 months. Multivariate analysis using baseline scores indicated several scales to be of prognostic value for the total cohort (ie, happiness today, role functioning, diarrhea, pancreatic pain, and body image; hazard ratios all P