Role of cortisol and superoxide dismutase in psychological stress induced anovulation
Role of cortisol and superoxide dismutase in psychological stress induced anovulation
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DOI：
10.1016/j.ygcen.2015.09.010
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发表时间：
2016-01-01
影响因子：
2.7
通讯作者：
Nivsarkar, Manish
中科院分区：
文献类型：
--
作者：
Kala, Manika;Nivsarkar, Manish
压力已被确定为生殖功能障碍的潜在触发因素，但压力对排卵影响背后的心理生理学途径尚未探索。目前的研究工作突出了心理应激对小鼠排卵的合理机制，通过靶向超氧化物歧化酶（SOD），一种参与排卵的酶。为此，进行了三项连续研究。第一项研究旨在确定心理压力引起的皮质醇水平、行为参数和正常动情周期变化的影响。随后的研究评估了超排卵对SOD亚型mRNA表达、卵巢组织切片中卵泡生长以及卵母细胞质量和数量差异的影响。结果表明，心理应激模型引起皮质醇水平升高（P
Stress has been identified as a potential trigger for reproductive dysfunctions, but the psychophysiological pathway behind the effect of stress on ovulation remains unexplored. The present research work highlights the plausible mechanism of psychological stress on ovulation in mice by targeting superoxide dismutase (SOD), an enzyme involved in ovulation. For this, three consecutive studies were carried out. The first study aimed to determine the effect of psychological stress induced change in cortisol level, behavioral parameters and normal estrous cyclicity. The effect on mRNA expression of SOD subtypes, follicular growth in histological sections of ovaries and the difference in oocyte quality and number, upon superovulation were assessed in the subsequent studies. The results indicate that psychological stress model causes an increase in cortisol level (p