Long-term endothelial changes in phakic eyes after Artisan intraocular lens implantation to correct myopia - Five-year study
Long-term endothelial changes in phakic eyes after Artisan intraocular lens implantation to correct myopia - Five-year study
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DOI：
10.1016/j.jcrs.2007.01.037
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发表时间：
2007-05-01
影响因子：
2.8
通讯作者：
Benedetti, Margherita
中科院分区：
文献类型：
--
作者：
Benedetti, Stefano;Casamenti, Virna;Benedetti, Margherita
目得：评价因中度至高度近视而植入虹膜切除有晶状体眼Artisan人工透镜（IOL）的患眼的长期内皮细胞变化。环境：Casa di Cura Villa Igea，安科纳，意大利.方法：前瞻性检查了30例49只眼植入Artisan IOL治疗中高度近视的患者。进行术前角膜内皮显微镜检查和连续术后角膜内皮显微镜检查（Noncon Robo SP 8000，Konan Medical），以评价5年内的内皮细胞变化。在术前和术后4、12、24、36、48和60个月收集角膜中心区域的内皮细胞图像。结果：术前平均内皮细胞密度（ECD）为2616个细胞/mm（2）+/- 347（SD），平均变异系数为39.6% +/-4.7%，平均六边形细胞百分比为49.2% +/-6.7%。与术前相比，4个月时的平均内皮细胞损失为2.3%，12个月时为3.5%，24个月时为4.7%，3年时为6.7%，4年时为8.3%，5年时为9.0%。术后5年，平均变异系数为35.9% +/- 6.9%（P = 0.1946），六边形细胞的百分比显著较高（平均54.7% +/- 10.3%）（P = 0.087）。结论：术后5年随访期间观察到持续的内皮细胞丢失，尤其是在前2年。随着时间的推移，观察到变异系数降低和六边形细胞百分比增加，反映了术后5年角膜内皮细胞的稳定性和重塑增加。
PURPOSE: To evaluate long-term endothelial cell changes in eyes that had implantation of an iris-tixated phakic Artisan intraocular lens (IOL) for moderate to high myopia. SETTING: Casa di Cura Villa Igea, Ancona, Italy.METHODS: Forty-nine eyes of 30 patients having implantation of Artisan IOL for moderate to high myopia were prospectively examined. Preoperative specular microscopy and serial postoperative specular microscopy (Noncon Robo SP 8000, Konan Medical) were performed to evaluate endothelial cell changes over 5 years. Endothelial cell images were collected in the central region of the cornea before surgery and 4, 12, 24, 36, 48, and 60 months after surgery. The endothelial cell density (ECD), coefficient of variation, and percentage of hexagonal cells were determined.RESULTS: Preoperatively, the mean ECD was 2616 cells/mm(2) +/- 347 (SD), the mean coefficient of variation was 39.6% +/- 4.7%, and the mean percentage of hexagonal cells was 49.2% +/- 6.7%. The mean endothelial cell loss from preoperatively was 2.3% at 4 months, 3.5% at 12 months, 4.7% at 24 months, 6.7% at 3 years, 8.3% at 4 years, and 9.0% at 5 years. Five years after surgery, the mean coefficient of variation was 35.9% +/- 6.9% (P = .1946) and the percentage of hexagonal cells was significantly higher (mean 54.7% +/- 10.3%) (P = .087).CONCLUSIONS: Continuous endothelial cell loss was observed after surgery during a 5-year followup, especially during the first 2 years. A decrease in the coefficient of variation and an increase in the percentage of hexagonal cells were observed over time, reflecting the increasing stability and remodeling of the corneal endothelial cells 5 years postoperatively.