Synthesis and characterization of fluorescent cobalamin (CobalaFluor) derivatives for imaging
Synthesis and characterization of fluorescent cobalamin (CobalaFluor) derivatives for imaging
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DOI：
10.1021/ol006825v
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发表时间：
2001-03-22
期刊：
影响因子：
5.2
通讯作者：
Grissom, CB
中科院分区：
文献类型：
--
作者：
Smeltzer, CC;Cannon, MJ;Grissom, CB
[GRAPHICS]Fluorescent derivatives of cobalamin have been prepared by linking fluorophores to cobalamin through a propylamide spacer. Fluorescein, naphthofluorescein, and Oregon Green derivatives have been prepared in good yield by reaction of the fluorophore NHS-ester with beta-(3-aminopropyl)cobalamin to form fluorescent cobalamin conjugates (CobalaFluors) that are potentially suitable for the in vitro and in vivo imaging of transcobalamin receptors on cancer cells.
