Mixed selectivity coding of sensory and motor social signals in the thalamus of a weakly electric fish.
Mixed selectivity coding of sensory and motor social signals in the thalamus of a weakly electric fish.
复制标题
弱电鱼丘脑中感觉和运动社会信号的混合选择性编码。
DOI：
10.1016/j.cub.2021.10.034
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Maler,Leonard
中科院分区：
文献类型：
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作者：
Wallach,Avner;Melanson,Alexandre;Longtin,André;Maler,Leonard
高水平的神经活动往往表现出对多元信号的混合选择性。这些表征是如何产生和调节自然行为的，人们知之甚少。我们在弱电鱼中解决了这个问题，弱电鱼的社会行为是相对低维的，可以很容易地在实验室中复制。我们报告说，肾小球前复合体，一个专门连接中脑和pallium的丘脑区域，实现了一种混合选择策略来编码与求爱和竞争相关的相互作用。我们讨论了这一代码如何使苍白循环网络控制社会行为，包括在雄性竞争和雌性配偶选择中的支配地位。值得注意的是，响应延迟分析和计算模型表明，运动前区域的必然放电与标记输出通信有关，从而消除了自生与非自生信号的歧义。这些发现为社会行为的神经基础、多维神经表征及其在感知和决策中的作用提供了新的见解。
High-level neural activity often exhibits mixed selectivity to multivariate signals. How such representations arise and modulate natural behavior is poorly understood. We addressed this question in weakly electric fish, whose social behavior is relatively low dimensional and can be easily reproduced in the laboratory. We report that the preglomerular complex, a thalamic region exclusively connecting midbrain with pallium, implements a mixed selectivity strategy to encode interactions related to courtship and rivalry. We discuss how this code enables the pallial recurrent networks to control social behavior, including dominance in male-male competition and female mate selection. Notably, response latency analysis and computational modeling suggest that corollary discharge from premotor regions is implicated in flagging outgoing communications and thereby disambiguating self- versus non-self-generated signals. These findings provide new insights into the neural substrates of social behavior, multi-dimensional neural representation, and its role in perception and decision making.