Tobacco smoking and breast cancer risk: An evaluation based on a systematic review of epidemiological evidence among the Japanese population
Tobacco smoking and breast cancer risk: An evaluation based on a systematic review of epidemiological evidence among the Japanese population
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DOI：
10.1093/jjco/hyl031
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发表时间：
2006-06-01
影响因子：
2.4
通讯作者：
Tsugane, Shoichiro
中科院分区：
文献类型：
--
作者：
Nagata, Chisato;Mizoue, Tetsuya;Tsugane, Shoichiro
背景资料：我们的研究小组对日本的癌症流行病学研究进行了评估，以评估有关健康生活方式与癌症之间关系的现有证据。由于吸烟可能是乳腺癌的少数几个可修改的危险因素之一，我们专注于吸烟和乳腺癌的风险之间的关联在此review.Methods：一个MEDLINE搜索进行了识别吸烟和乳腺癌的发病率或死亡率之间的关联的流行病学研究在日本1966年至2005年。协会的评估是基于证据的强度和关联的程度，连同生物学的可接受性，如以前评估的国际癌症研究机构onCancer.Results：三个队列研究和八个病例对照研究确定。在这些研究中，目前吸烟者患乳腺癌的相对危险度（RR）或比值比（OR）范围为0.71至6.26。在三项队列研究中，有一项报告称，与从不吸烟者相比，目前吸烟者的风险显著增加（RR = 1.7）。在8项病例对照研究中，有4项研究观察到吸烟与乳腺癌风险之间存在中度或高度相关性（OR > 2.0）。实验研究已经支持了生物学上的可接受性吸烟和乳腺癌risk.Conclusion之间的正相关：我们得出结论，吸烟可能会增加日本人口中乳腺癌的风险。
Background: Our research group undertook an appraisal of the body of epidemiological studies on cancer in Japan to evaluate the existing evidence concerning the association between health-related lifestyles and cancer. As tobacco smoking may be one of the few modifiable risk factors for breast cancer, we focused on the association between tobacco smoking and the risk of breast cancer in this review.Methods: A MEDLINE search was conducted to identify epidemiological studies on the association between smoking and breast cancer incidence or mortality among the Japanese from 1966 to 2005. Evaluation of associations was based on the strength of evidence and the magnitude of association, together with biological plausibility as previously evaluated by the International Agency for Research on Cancer.Results: Three cohort studies and eight case-control studies were identified. The relative risk (RR) or odds ratio (OR) of breast cancer for current smokers ranged from 0.71 to 6.26 in these studies. A significantly increased risk among current smokers compared with never smokers (RR = 1.7) was reported in one out of the three cohort studies. Moderate or strong associations between smoking and breast cancer risk (OR > 2.0) were observed in four of the eight case-control studies. Experimental studies have supported the biological plausibility of a positive association between tobacco smoking and breast cancer risk.Conclusion: We conclude that tobacco smoking possibly increases the risk of breast cancer in the Japanese population.