Imaging the Role of Inflammation in Mood and Anxiety-related Disorders.
Imaging the Role of Inflammation in Mood and Anxiety-related Disorders.
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DOI：
10.2174/1570159x15666171123201142
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发表时间：
2018
影响因子：
5.3
通讯作者：
Felger JC
中科院分区：
文献类型：
--
作者：
Felger JC
调查各种炎症刺激对大脑和行为的影响的研究报告了炎症和炎性细胞因子的释放影响与奖励和威胁敏感性相关的回路以促进行为改变的证据。与情绪和焦虑相关的疾病，炎症的生物标志物，如炎性细胞因子和急性期蛋白质，可靠地升高，在一个显着比例的患者患有重度抑郁症（MDD），双相情感障碍，焦虑症和创伤后应激障碍（PTSD）。本文综述了外周炎症对奖励和威胁敏感性相关脑区和神经递质系统的影响的临床和翻译工作，重点是涉及炎症刺激管理的神经影像学研究。最近翻译这些发现，以进一步了解炎症的作用，情绪和焦虑相关的疾病也进行了讨论。炎症一直被发现影响基底神经节和皮质奖励和运动回路，以驱动减少的动机和运动活动，以及焦虑相关的大脑区域，包括杏仁核，杏仁核和前扣带皮层，这可能是由于细胞因子对单胺和谷氨酸的影响。在外周炎症标志物增加的MDD患者中观察到炎症和神经回路改变之间的类似关系，并且这种工作即将用于焦虑症和PTSD。炎症对奖励和威胁回路的神经成像作用可用作炎症的生物标志物，用于未来开发新的治疗策略，以更好地治疗高度炎症患者的情绪和焦虑相关疾病。
Studies investigating the impact of a variety of inflammatory stimuli on the brain and behavior have reported evidence that inflammation and release of inflammatory cytokines affect circuitry relevant to both reward and threat sensitivity to contribute to behavioral change. Of relevance to mood and anxiety-related disorders, biomarkers of inflammation such as inflammatory cytokines and acute-phase proteins are reliably elevated in a significant proportion of patients with major depressive disorder (MDD), bipolar disorder, anxiety disorders and post-traumatic stress disorder (PTSD). This review summarized clinical and translational work demonstrating the impact of peripheral inflammation on brain regions and neurotransmitter systems relevant to both reward and threat sensitivity, with a focus on neuroimaging studies involving administration of inflammatory stimuli. Recent translation of these findings to further understand the role of inflammation in mood and anxiety-related disorders is also discussed. Inflammation was consistently found to affect basal ganglia and cortical reward and motor circuits to drive reduced motivation and motor activity, as well as anxiety-related brain regions including amygdala, insula and anterior cingulate cortex, which may result from cytokine effects on monoamines and glutamate. Similar relationships between inflammation and altered neurocircuitry have been observed in MDD patients with increased peripheral inflammatory markers, and such work is on the horizon for anxiety disorders and PTSD. Neuroimaging effects of inflammation on reward and threat circuitry may be used as biomarkers of inflammation for future development of novel therapeutic strategies to better treat mood and anxiety-related disorders in patients with high inflammation.