Activity profiles of single neurons in caudal anterior cingulate cortex during trace eyeblink conditioning in the rabbit
Activity profiles of single neurons in caudal anterior cingulate cortex during trace eyeblink conditioning in the rabbit
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DOI：
10.1152/jn.01097.2002
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发表时间：
2003-08-01
影响因子：
2.5
通讯作者：
Disterhoft, JF
中科院分区：
文献类型：
--
作者：
Weible, AP;Weiss, C;Disterhoft, JF
获取轨迹眨眼条件反射涉及条件刺激（CS）与由无刺激轨迹间隔隔开的非条件刺激（US）的关联。这种形式的条件反射依赖于海马和尾侧前扣带皮层（AC），以及脑干和小脑回路。海马参与痕迹眨眼条件反射已被广泛研究，但参与尾部AC是不太了解。在本研究中，我们比较了兔子的神经元反应，无论是配对（跟踪条件）或不配对（pseudoconditioning）介绍CS和US。介绍的CS引起显着增加神经元的活动在发病的痕迹调理和pseudoconditioning。一个强大的CS引起的神经元反应持续整个跟踪条件反射的前2天，在随后的训练课程逐渐下降。相比之下，CS引起的兴奋性反应在伪条件反射的幅度开始下降，在前10个试验。神经元表现出兴奋性反应的CS在跟踪条件也表现出兴奋性反应的美国，显着更大的幅度比美国引起的反应在pseudoconditioning。CS引起的神经元活动的减少变得更加强大的过程中的跟踪条件相比，pseudoconditioning。在CS间隔的活动减少一致之前，在两个训练组的兴奋，这表明CS引起的神经元活动的减少可能有助于增加的信号噪声比的兴奋性反应的音调。两者合计，这些数据表明，尾侧AC参与早期跟踪眨眼条件和维护CS引起的兴奋性反应可能有助于信号的音调的显着性。
Acquisition of trace eyeblink conditioning involves the association of a conditioned stimulus ( CS) with an unconditioned stimulus ( US) separated by a stimulus-free trace interval. This form of conditioning is dependent upon the hippocampus and the caudal anterior cingulate cortex (AC), in addition to brain stem and cerebellar circuitry. Hippocampal involvement in trace eyeblink conditioning has been studied extensively, but the involvement of caudal AC is less well understood. In the present study, we compared neuronal responses from rabbits given either paired ( trace conditioning) or unpaired (pseudoconditioning) presentations of the CS and US. Presentation of the CS elicited significant increases in neuronal activity at the onset of both trace conditioning and pseudoconditioning. A robust CS-elicited neuronal response persisted throughout the first 2 days of trace conditioning, declining gradually across subsequent training sessions. In contrast, the magnitude of the CS-elicited excitatory response during pseudoconditioning began to decline within the first 10 trials. Neurons exhibiting excitatory responses to the CS during trace conditioning also exhibited excitatory responses to the US that were significantly greater in magnitude than US-elicited responses during pseudoconditioning. CS-elicited decreases in neuronal activity became more robust over the course of trace conditioning compared to pseudoconditioning. Reductions in activity during the CS interval consistently preceded excitation in both training groups, suggesting that the CS-elicited decreases in neuronal activity may serve to increase the signal-to-noise ratio of the excitatory response to the tone. Taken together, these data suggest that the caudal AC is involved early in trace eyeblink conditioning and that maintenance of the CS-elicited excitatory response may serve to signal the salience of the tone.