Cobalt hexacyanoferrate modified multi-walled carbon nanotubes/graphite composite electrode as electrochemical sensor on microfluidic chip
Cobalt hexacyanoferrate modified multi-walled carbon nanotubes/graphite composite electrode as electrochemical sensor on microfluidic chip
复制标题
六氰基铁酸钴修饰多壁碳纳米管/石墨复合电极作为微流控芯片电化学传感器
DOI：
10.1016/j.aca.2011.10.035
复制
发表时间：
2012-01-13
影响因子：
6.2
通讯作者：
Liang, Yajing
中科院分区：
文献类型：
--
作者：
Li, Xinchun;Chen, Zuanguang;Liang, Yajing
基于纳米材料的电化学传感器受到了极大的关注。本工作采用电化学方法制备了六氰基铁酸钴修饰的多壁碳纳米管/石墨复合电极，并将其作为芯片电泳法的安培检测器。由于铁氰化钴和多壁碳纳米管的协同电催化作用，所制备的传感器对肼和异烟肼的氧化具有快速而灵敏的响应。与裸碳糊电极相比，灵敏度提高了近两个数量级，对肼的检出限为0.91muM(S/N=3)。在不经芯片和电极处理的情况下，连续11次进样联氨，对峰电流和迁移时间的相对标准偏差分别为3.4%和2.1%。同时观察到形状良好的电泳峰，这主要是由于电活性物质在修饰电极上的快速电子转移所致。所研制的微芯片电化学仪已成功应用于河水和药物制剂中肼和异烟肼的测定。新型电化学传感器与微流控平台联用，具有相对稳定、制作简单、灵敏度高等优点，在联氨类化合物的芯片实验室检测中具有广阔的应用前景。(C)2011爱思唯尔B.V.保留所有权利。
Nanomaterial-based electrochemical sensor has received significant interest. In this work, cobalt hexacyanoferrate modified multi-walled carbon nanotubes/graphite composite electrode was electrochemically prepared and exploited as an amperometric detector for microchip electrophoresis. The prepared sensor displayed rapid and sensitive response towards hydrazine and isoniazid oxidation, which was attributed to synergetic electrocatalytic effect of cobalt hexacyanoferrate and multi-walled carbon nanotubes. The sensitivity enhancement with nearly two orders of magnitude was gained, compared with the bare carbon paste electrode, with the detection limit of 0.91 mu M (S/N=3) for hydrazine. Acceptable repeatability of the microanalysis system was verified by consecutive eleven injections of hydrazine without chip and electrode treatments, the RSDs for peak current and migration time were 3.4% and 2.1%, respectively. Meanwhile, well-shaped electrophoretic peaks were observed, mainly due to fast electron transfer of electroactive species on the modified electrode. The developed microchip-electrochemistry setup was successfully applied to the determination of hydrazine and isoniazid in river water and pharmaceutical preparation, respectively. Several merits of the novel electrochemical sensor coupled with microfluidic platform, such as comparative stability, easy fabrication and high sensitivity, hold great potential for hydrazine compounds assay in the lab-on-a-chip system. (C) 2011 Elsevier B.V. All rights reserved.