A requirement for the immediate early gene zif268 in reconsolidation of recognition memory after retrieval
A requirement for the immediate early gene zif268 in reconsolidation of recognition memory after retrieval
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DOI：
10.1016/s0896-6273(03)00674-3
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发表时间：
2003-11-13
期刊：
影响因子：
16.2
通讯作者：
Laroche, S
中科院分区：
文献类型：
--
作者：
Bozon, B;Davis, S;Laroche, S
最近的研究重新燃起了人们对以前巩固的记忆需要重新巩固的可能性的兴趣，当回忆起时，需要重新巩固才能回到可访问的长期记忆。有证据表明，巩固和重新巩固某些类型的记忆都需要蛋白质合成，但是否涉及类似的分子机制尚不清楚。在这里，我们探索Zif268，一个活性依赖的可诱导的即刻早期基因(IEG)，在新的记忆巩固中是否也被招募来在重新激活后重新巩固识别记忆。我们发现，当对物体的巩固记忆被回忆时，Zif268突变小鼠在进一步的长期但不是短期识别记忆中受到损害。这种损伤是与先前记忆的物体在相关背景下的重新激活有关的，发生在延迟回忆中，并不会在几天内恢复。这些发现表明，IEG介导的神经元转录调控是储存新形成和重新激活的识别记忆的一种常见的分子机制。
Recent research has revived interest in the possibility that previously consolidated memories need to reconsolidate when recalled to return to accessible long-term memory. Evidence suggests that both consolidation and reconsolidation of certain types of memory require protein synthesis, but whether similar molecular mechanisms are involved remains unclear. Here, we explore whether zif268, an activity-dependent inducible immediate early gene (IEG) required for consolidation of new memories, is also recruited for reconsolidation of recognition memory following reactivation. We show that when a consolidated memory for objects is recalled, zif268 mutant mice are impaired in further long-term but not short-term recognition memory. The impairment is specific to reactivation with the previously memorized objects in the relevant context, occurs in delayed recall, and does not recover over several days. These findings indicate that IEG-mediated transcriptional regulation in neurons is one common molecular mechanism for the storage of newly formed and reactivated recognition memories.