Roles of Hsp90 in Candida albicans morphogenesis and virulence.
Roles of Hsp90 in Candida albicans morphogenesis and virulence.
复制标题
Hsp90 在白色念珠菌形态发生和毒力中的作用。
DOI：
10.1016/j.mib.2023.102351
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发表时间：
2023
影响因子：
5.4
通讯作者：
Cowen,LeahE
中科院分区：
文献类型：
--
作者：
Robbins,Nicole;Cowen,LeahE
亮点Hsp90 是一种分子伴侣，可调节许多客户蛋白的功能。形态发生是白色念珠菌的重要毒力特征。Hsp90 通过复杂的机制调节白色念珠菌形态发生和毒力。靶向真菌 Hsp90 是对抗真菌疾病的一种有前景的治疗策略。Hsp90 是一种保守的分子伴侣，可促进数百种客户蛋白的折叠和功能，其中许多服务于作为信号转导网络的核心枢纽。 Hsp90 在机会性真菌病原体白色念珠菌的毒力中起着至关重要的作用，白色念珠菌作为人类微生物群的天然共生体存在，是侵袭性真菌感染的主要原因，特别是在免疫功能低下的个体中。白色念珠菌引起疾病的能力与其在酵母和丝状形式之间进行形态发生转变的能力紧密相关。在这里，我们描述了 Hsp90 调节白色念珠菌形态发生和毒力的复杂机制，并探索了靶向真菌 Hsp90 作为对抗真菌感染的治疗策略的潜力。
HighlightsHsp90 is a molecular chaperone that modulates the function of many client proteins.Morphogenesis is an important Candida albicans virulence trait.Hsp90 regulates C. albicans morphogenesis and virulence through complex mechanisms.Targeting fungal Hsp90 is a promising therapeutic strategy to combat fungal disease.Hsp90 is a conserved molecular chaperone that facilitates the folding and function of hundreds of client proteins, many of which serve as core hubs of signal transduction networks. Hsp90 has a critical role in virulence of the opportunistic fungal pathogen Candida albicans, which exists as a natural commensal of the human microbiota and is a leading cause of invasive fungal infections, particularly in immunocompromised individuals. The ability of C. albicans to cause disease is tightly coupled to its capacity to undergo a morphogenetic transition between yeast and filamentous forms. Here, we describe the complex mechanisms by which Hsp90 regulates C. albicans morphogenesis and virulence, and explore the potential of targeting fungal Hsp90 as a therapeutic strategy to combat fungal infections.