Social Stress and Aggression in Murine Models
Social Stress and Aggression in Murine Models
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小鼠模型中的社会压力和攻击性
DOI：
10.1007/7854_2021_243
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发表时间：
2021
期刊：
影响因子：
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通讯作者：
Takahashi A
中科院分区：
文献类型：
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作者：
Katayama Yukitoshi;Tsukada Takehiro;Hyodo Susumu;Sakamoto Hirotaka;Sakamoto Tatsuya;Takahashi A
在整个生命过程中，动物参与各种各样的社会互动，从亲和的母子互动和少年游戏到攻击性冲突。在早期发展过程中，适当的社会互动的延迟是有压力的，并且会破坏适当的社会行为和情感反应的发展。此外，对抗性遭遇会引起支配和从属个体的应激反应。本文综述了导致动物攻击行为升级的社会应激，并讨论了社会应激与攻击行为之间联系的神经生物学和生理学机制。社会煽动，一个短暂的暴露在竞争对手没有身体接触，诱导侵略性唤醒占主导地位的动物和升级的攻击行为，在接下来的竞争遭遇。此外，赢得攻击性遭遇的经验被认为是成瘾性药物的奖励，反复获胜的经验会引起成瘾样的行为和神经生物学变化，并导致异常的攻击性行为。从新生儿到少年和青少年时期的早期发育中的社会隔离压力也会影响攻击行为，但这些影响在很大程度上取决于菌株，性别和物种以及经历隔离压力的发育阶段。总之，了解社会压力和侵略之间的联系的神经生物学机制将提供一个重要的见解，为发展更有效和更宽容的治疗人类适应不良的侵略。
Throughout life, animals engage in a variety of social interactions ranging from the affiliative mother–offspring interaction and juvenile play to aggressive conflict. Deprivation of the appropriate social interaction during early development is stressful and disrupts the development of appropriate social behaviors and emotional responses later in life. Additionally, agonistic encounters can induce stress responses in both dominant and subordinate individuals. This review focuses on the social stress that escalates aggressive behavior of animals and discusses the known neurobiological and physiological mechanisms underlying the link between social stress and aggression. Social instigation, a brief exposure to a rival without physical contact, induces aggressive arousal in dominant animals and escalates aggressive behaviors in the following agonistic encounter. Furthermore, the experience of winning an aggressive encounter is known to be as rewarding as addictive drugs, and the experience of repeatedly winning induces addiction-like behavioral and neurobiological changes and leads to abnormal aggressive behaviors. Social isolation stress in early development from neonatal to juvenile and adolescent periods also affects aggressive behavior, but these effects largely depend on the strain, sex, and species as well as the stage of development in which isolation stress is experienced. In conclusion, understanding neurobiological mechanisms underlying the link between social stress and aggression will provide an important insight for the development of more effective and tolerable treatments for maladaptive aggression in humans.