Reduced hippocampal functional connectivity in Alzheimer disease
Reduced hippocampal functional connectivity in Alzheimer disease
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DOI：
10.1001/archneur.64.10.1482
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发表时间：
2007-10-01
影响因子：
--
通讯作者：
Cullum, C. Munro
中科院分区：
文献类型：
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作者：
Allen, Greg;Barnard, Holly;Cullum, C. Munro
目的：探讨阿尔茨海默病患者海马区的功能连通性是否降低。设计：采用功能连通性磁共振成像技术，研究阿尔茨海默病患者海马区与其他脑区磁共振信号的一致性。受试者：8名可能患有阿尔茨海默病的患者和8名健康志愿者。结果：对照组显示海马区功能连通性与弥漫性皮质、皮质下和小脑部位相连，而患者表现出明显的功能连通性降低，包括与额叶的连通性缺失。结论：这些发现提示阿尔茨海默病患者海马区和其他脑区之间存在功能脱节。
Objective: To determine if functional connectivity of the hippocampus is reduced in patients with Alzheimer disease.Design: Functional connectivity magnetic resonance imaging was used to investigate coherence in the magnetic resonance signal between the hippocampus and all other regions of the brain.Participants: Eight patients with probable Alzheimer disease and 8 healthy volunteers.Results: Control subjects showed hippocampal functional connectivity with diffuse cortical, subcortical, and cerebellar sites, while patients demonstrated markedly reduced functional connectivity, including an absence of connectivity with the frontal lobes.Conclusion: These findings suggest a functional disconnection between the hippocampus and other brain regions in patients with Alzheimer disease.