RELATIONSHIP BETWEEN CYTO-TOXIC NECROTIZING FACTOR PRODUCTION AND SEROTYPE IN HEMOLYTIC ESCHERICHIA-COLI
RELATIONSHIP BETWEEN CYTO-TOXIC NECROTIZING FACTOR PRODUCTION AND SEROTYPE IN HEMOLYTIC ESCHERICHIA-COLI
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DOI：
10.1128/jcm.27.4.758-761.1989
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发表时间：
1989-04-01
影响因子：
9.4
通讯作者：
DONELLI, G
中科院分区：
文献类型：
--
作者：
CAPRIOLI, A;FALBO, V;DONELLI, G
我们研究了从粪便和肠外感染中分离的123株大肠杆菌溶血性菌株的血清型与细胞毒性坏死因子（CNF）产生之间的关系。在76名同时产生溶血素（Hly）和CNF的Strians中，66名（87%）属于isx血清群之一（O2、O4、O6、O22、O75和083）。47 E.产Hly的大肠杆菌菌株仅属于21个不同的O血清群，其中只有2个（O6和O18ac）具有广泛代表性。通常，CNF阳性和CNF阴性溶血分离株被分配到不同的O血清群，但O6除外，O6通常存在于两类分离株中。血清群O4和O18ac显着更流行的菌株肠外感染比粪便中。相反，Hly阳性，CNF阴性分离株，属于许多不太常见的血清群，几乎从来没有分离肠外感染。血清学分型进一步证实溶血性E.根据CNF的产生能力，大肠杆菌可大致分为两个主要群体。溶血性E.大肠杆菌的这种性质也可能有助于实现病原性克隆的更详细的表征。
We examined the relationship between serotype and cytotoxic necrotixing factor (CNF) production in 123 hemolytic strin of Escherichia coli isolated from both stools and extraintestinal infections. Of 76 strians, producing both hemolysin (Hly) and CNF, 66 (87%) belonged to one of isx serogroups (O2, O4, O6, O22, O75, and 083). In contrast, 47 E. coli strains producing Hly only belonged to 21 different O serogroups, and only 2 of these (O6 and O18ac) were widely represented. Generally, CNF-positive and CNF-negative hemolytic isolates were assigned to different O serogroups, with the exception of O6, often present in both categories of isolates. Serogroups O4 and O18ac were significantly more prevalent among strains from extraintestinal infections than among those from stools. In contrast, the Hly-positive, CNF-negative isolates, belonging to numerous less common serogroups, were hardly ever isolated form extraintestinal infections. Serological typing further confirmed that hemolytic isolates of E. coli may grossly be divided into two main populations on the basis of the ability to produce CNF. Examination of hemolytic E. coli for this property may also be useful in achieving a more detailed characterization of pathogenic clones.