HLA-DR-associated isotype-specific regulation of antibody levels to mycobacteria in rheumatoid arthritis.
HLA-DR-associated isotype-specific regulation of antibody levels to mycobacteria in rheumatoid arthritis.
复制标题
类风湿性关节炎中分枝杆菌抗体水平的 HLA-DR 相关同种型特异性调节。
DOI：
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复制
发表时间：
1988
影响因子：
4.6
通讯作者：
K. Behbehani
中科院分区：
文献类型：
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作者：
G. Bahr;G. Rook;A. Shahin;J. Stanford;M. Sattar;K. Behbehani
Using sera from 75 healthy donors, 68 rheumatoid arthritis (RA) patients, and 85 tuberculosis (TB) patients, we have examined the level of antibody of the three major classes binding to seven mycobacterial species, and to three control antigens. The major findings are that IgM binding to mycobacteria is reduced in RA patients who have HLA-DR7 (P = 0.008 for M. tuberculosis antigen), and that IgA binding to mycobacteria is reduced in RA patients who have HLA-DR2 (P = 0.007 for M. tuberculosis; P = 0.0004 for M. nonchromogenicum). These associations were not seen in TB, and were restricted to these antibody isotypes. We believe this is the first report of isotype specific Class II MHC-associated regulation of antibody levels in man. A possible interpretation of our data is that patients bearing these haplotypes are recognizing suppressor epitopes common to all the mycobacterial species tested. Since DR2 and DR7 have recently been shown to be associated with a significantly reduced risk of RA, our findings are compatible with the view that changes in immune responsiveness to mycobacterial antigens, or to autoantigens which cross-react with them, are relevant to RA.
