Tumor Cell Growth Inhibition Is Correlated With Levels of Capsaicin Present in Hot Peppers
Tumor Cell Growth Inhibition Is Correlated With Levels of Capsaicin Present in Hot Peppers
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DOI：
10.1080/01635581.2011.523497
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发表时间：
2011-01-01
影响因子：
2.9
通讯作者：
Sarkar, Fazlul H.
中科院分区：
文献类型：
--
作者：
Dou, Dan;Ahmad, Aamir;Sarkar, Fazlul H.
关于辣椒及其主要活性成分辣椒素作为抗癌剂的价值，存在相互矛盾的报道。我们测试了多种辣椒的提取物，发现它们在体外能显著诱导人乳腺癌和白血病癌细胞系的生长停滞和凋亡，而对正常乳腺上皮细胞无显著影响。此外，细胞生长抑制和细胞死亡诱导与辣椒的辣椒素含量（基于史高维尔指标）呈正相关，羟基自由基清除剂硫脲显著抑制辣椒提取物的活性，这表明自由基参与介导辣椒提取物的生物活性。这些结果表明辣椒提取物作为抗癌剂具有潜在用途。
There are conflicting reports with regard to the value of hot peppers and their primary active component compound, capsaicin, as an anticancer agent. We tested extracts from a number of peppers and found them to induce significant growth arrest and apoptosis in human breast and leukemia cancer cell lines in vitro with no significant effect on normal breast epithelial cells. Further, cell growth inhibition and cell death induction were positively correlated with the capsaicin content (based on the Scoville scale) of the peppers, and the hydroxyl radical scavenger thiourea significantly inhibited the activity of pepper extracts, suggesting the involvement of free radicals in mediating the biological activity of the pepper extracts. These results suggest a potential use of pepper extracts as anticancer agents.