The Effect of Financial Conflict of Interest, Disclosure Status, and Relevance on Medical Research from the United States
The Effect of Financial Conflict of Interest, Disclosure Status, and Relevance on Medical Research from the United States
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DOI：
10.1007/s11606-018-4784-0
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发表时间：
2019-03-01
影响因子：
5.7
通讯作者：
Liang, Mike K.
中科院分区：
文献类型：
--
作者：
Cherla, Deepa V.;Viso, Cristina P.;Liang, Mike K.
行业和医疗保健提供者之间的财务互动是可报告的。在这些利益冲突（coi）的行业和自我报告之间已经发现了实质性的差异。我们的目的是确定未披露可报告COI的作者是否比没有COI的作者更有可能发表对行业有利的研究结果。在这项盲法、观察性研究中，对PubMed上的医学和外科主要研究文章进行了审查，共590篇文章。评估了作者与行业之间可报告的财务关系。如果coi与文章中提到的产品相关联，则认为它们具有相关性。主要结局是好感度，定义为对一篇文章讨论的产品的好感度，每篇文章由3名独立的盲法临床医生确定。初步分析比较了不完全自我表露与无COI。采用双水平多变量混合效应有序逻辑回归来评估与好感度相关的因素。关键结果行业与自我报告在COI信息披露方面存在69%的不一致性。当作者没有披露COI时，他们的结论比没有COI的作者更倾向于行业合作伙伴（73%对62%，RR 1.18, p=< 0.001）。在单变量分析（有COI的74%对没有COI的62%，RR 1.11, p=< 0.001）和多变量分析中，任何COI都与好感度相关。所有财务coi（披露或未披露，相关或不相关，研究或非研究）都会影响研究是否报告有利于行业赞助商的结果。
BackgroundFinancial interactions between industry and healthcare providers are reportable. Substantial discrepancies have been detected between industry and self-report of these conflicts of interest (COIs).ObjectiveOur aim was to determine if authors who fail to disclose reportable COI are more likely to publish findings that are favorable to industry than authors with no COI.DesignIn this blinded, observational study of medical and surgical primary research articles in PubMed, 590 articles were reviewed.Main MeasuresReportable financial relationships between authors and industry were evaluated. COIs were considered to have relevance if they were associated with the product(s) mentioned by an article. Primary outcome was favorability, defined as an impression favorable to the product(s) discussed by an article and determined by 3 independent, blinded clinicians for each article. Primary analysis compared Incomplete Self-Disclosure to No COI. Two-level multivariable mixed-effects ordered logistic regression was used to assess factors associated with favorability.Key ResultsA 69% discordance rate existed between industry and self-report in COI disclosure.When authors failed to disclose COI, their conclusions were more likely to favor industry partners than authors without COI (favorable ratings 73% versus 62%, RR 1.18, p=< 0.001). On univariate (any COI 74% versus no COI 62%, RR 1.11, p=< 0.001) and multivariable analyses, any COI was associated with favorability.ConclusionsAll financial COIs (disclosed or undisclosed, relevant or not relevant, research or non-research) influence whether studies report findings favorable to industry sponsors.