Follicle stimulating hormone, its novel association with sex hormone binding globulin in men and postmenopausal women
Follicle stimulating hormone, its novel association with sex hormone binding globulin in men and postmenopausal women
复制标题
卵泡刺激素，其与男性和绝经后女性性激素结合球蛋白的新关联。
DOI：
10.1007/s12020-017-1272-y
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发表时间：
2017-06-01
期刊：
影响因子：
3.7
通讯作者：
Lu, Yingli
中科院分区：
文献类型：
--
作者：
Wang, Ningjian;Zhang, Kun;Lu, Yingli
卵泡刺激素在多种非性腺组织中发挥直接作用，性激素结合球蛋白正成为代谢性疾病间相互交叉的汇聚点。然而，没有研究探讨卵泡刺激素和性激素结合球蛋白之间的关联。我们的目的是研究男性和女性之间的这种关联。SPECT-China是一项自2014年以来进行的基于人群的研究。这项研究包括4206名男性和2842名绝经后女性。收集的血清进行分析促性腺激素，性激素结合球蛋白，性激素等进行回归分析，以评估性激素结合球蛋白和促卵泡激素和其他变量，包括代谢因素，甲状腺功能和性激素之间的关系。用0、5、50和100 IU/L的卵泡刺激素处理HepG 2细胞24 h，在斯皮尔曼相关分析中，男性和绝经后女性性激素结合球蛋白与FSH、甘油三酯、甲状腺素、体重指数和血压均显著相关（P均< 0.05）。在回归分析中，卵泡刺激素是男性和绝经后女性性激素结合球蛋白的显著预测因子（P < 0.05），与上述变量无关。促卵泡激素以剂量依赖方式诱导HepG 2细胞性激素结合球蛋白表达。男性和绝经后女性血清促卵泡激素水平与循环性激素结合球蛋白水平呈正相关。这种关联与年龄、胰岛素抵抗、肝功能、血脂、甲状腺功能、肥胖、血压和内源性激素无关。
Follicle stimulating hormone plays direct roles in a variety of nongonadal tissues and sex hormone binding globulin is becoming the convergence of the crosstalk among metabolic diseases. However, no studies have explored the association between follicle stimulating hormone and sex hormone binding globulin. We aimed to study this association among men and women.SPECT-China is a population-based study conducted since 2014. This study included 4206 men and 2842 postmenopausal women. Collected serum was assayed for gonadotropins, sex hormone binding globulin, sex hormones etc. Regression analyses were performed to assess the relationship between sex hormone binding globulin and follicle stimulating hormone and other variables including metabolic factors, thyroid function and sex hormones. Treatment with follicle stimulating hormone at different concentrations of 0, 5, 50 and 100 IU/L for 24 h was performed in HepG2 cells.In Spearman correlation, sex hormone binding globulin was significantly correlated with FSH, triglycerides, thyroxins, body mass index and blood pressure in men and postmenopausal women (all P < 0.05). In regression analyses, follicle stimulating hormone was a significant predictor of sex hormone binding globulin in men and postmenopausal women (P < 0.05), independent of above variables. Follicle stimulating hormone induced sex hormone binding globulin expression in a dose-dependent fashion in HepG2 cells.Serum follicle stimulating hormone levels were positively associated with circulating sex hormone binding globulin levels in men and postmenopausal women. This association is independent of age, insulin resistance, hepatic function, lipid profile, thyroid function, adiposity, blood pressure, and endogenous sex hormones.