CHANGES IN THE BASAL DENDRITES OF CORTICAL PYRAMIDAL CELLS FROM ALCOHOLIC PATIENTS - A QUANTITATIVE GOLGI-STUDY
CHANGES IN THE BASAL DENDRITES OF CORTICAL PYRAMIDAL CELLS FROM ALCOHOLIC PATIENTS - A QUANTITATIVE GOLGI-STUDY
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DOI：
10.1136/jnnp.53.10.856
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发表时间：
1990-10-01
影响因子：
11
通讯作者：
CORBETT, D
中科院分区：
文献类型：
--
作者：
HARPER, C;CORBETT, D
虽然各种病理变化已被描述在慢性酒精中毒患者的大脑中，一直没有研究已经解决了皮质神经元树突分支的改变的问题。在慢性酒精中毒患者中记录了上级额回神经元的丢失以及上级额回和运动皮层神经元的萎缩;这些区域被选择用于本研究。使用改良的快速高尔基体技术的第三层锥体神经元的基础树突状分支进行了比较，在15名男性酗酒患者和15名年龄匹配的男性对照。所有测量基底树突分支的参数在酒精中毒的情况下，无论是上级额叶和运动皮质都显着减少。乔木的变化是在终端分支，这是与其他模型的树突可塑性。这些变化可以解释慢性酒精中毒患者永久性和可逆性的功能缺陷。
Although a variety of pathological changes have been described in the brains of chronic alcoholic patients, there have been no studies which have addressed the question of alterations in cortical neuronal dendritic arborisation. Loss of neurons from the superior frontal gyrus and shrinkage of neurons from both the superior frontal gyrus and motor cortex has been documented in chronic alcoholic patients; these areas were chosen for this study. Using a modified rapid Golgi technique the basal dendritic arborisation of layer III pyramidal neurons was compared in 15 male alcoholic patients and 15 age-matched male controls. All parameters measuring basal dendritic arborisation were significantly less in the alcoholic cases for both the superior frontal and motor cortices. Changes in the arbor are in the terminal branches, which is consistent with other models of dendritic plasticity. Such changes may explain both permanent and reversible functional deficits in chronic alcoholic patients.