A PHEROMONE INFLUENCES LARVAL DEVELOPMENT IN THE NEMATODE CAENORHABDITIS-ELEGANS
A PHEROMONE INFLUENCES LARVAL DEVELOPMENT IN THE NEMATODE CAENORHABDITIS-ELEGANS
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DOI：
10.1126/science.6896933
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发表时间：
1982-01-01
期刊：
影响因子：
56.9
通讯作者：
RIDDLE, DL
中科院分区：
文献类型：
--
作者：
GOLDEN, JW;RIDDLE, DL
一种小杆线虫特有的信息素和食物供应影响进入和退出发育停滞的少年阶段，称为dauer幼虫。该信息素增加dauer幼虫形成的频率，抑制恢复，但不影响成虫的行为，如趋化性和产卵。脂肪酸类信息素的部分纯化，其特征在于一个新的生物测定。如果寄生线虫使用类似的发育控制机制，则可以利用这种机制来开发高选择性的驱虫剂。
A Caenorhabditis-specific pheromone and the food supply influence both entry into and exit from a developmentally arrested juvenile stage called the dauer larva. The pheromone increases the frequency of dauer larva formation and inhibits recovery but does not affect adult behavior such as chemotaxis and egg laying. The fatty acid-like pheromone was partially purified and characterized by a new bioassay. If similar developmental control mechanisms are used by parasitic nematodes, such mechanisms might be exploited to develop highly selective anthelmintic agents.