5,4 '-Dihydroxy-7,8-dimethoxyflavanone and Aliarin from Dodonaea viscosa Are Activators of PPAR gamma
5,4 '-Dihydroxy-7,8-dimethoxyflavanone and Aliarin from Dodonaea viscosa Are Activators of PPAR gamma
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DOI：
10.1055/s-0043-120270
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发表时间：
2018
期刊：
影响因子：
2.7
通讯作者：
Wang HY
中科院分区：
文献类型：
--
作者：
Zhu Jing-jie;Wang He-Yao;Ji Jun;Hou Ai-Jun;Zhu Jing-jie;Hou AJ;Wang HY
PPARγ激动剂是糖尿病治疗中广泛使用的药物。它们在改善脂肪组织功能方面的作用有助于抗糖尿病作用。已报道Dodonaea viscosa提取物具有抗糖尿病活性。然而，有效的介质和潜在的机制在很大程度上是未知的。本实验研究了D. viscosa、5，4 ′-二羟基-7，8-二甲氧基黄烷酮和茜素。结果表明，5，4 ′-二羟基-7，8-二甲氧基黄烷酮和茜素是潜在的部分PPARγ激动剂。化合物诱导3 T3-L1细胞中的脂肪生成，上调脂联素mRNA水平并增强胰岛素敏感性。5，4 ′-二羟基-7，8-二甲氧基黄烷酮、茜素等黄酮类成分对脂肪细胞的有利作用可能是D.粘的。
PPARγagonists are widely used medications in diabetes mellitus therapy. Their role in improving adipose tissue function contributes to antidiabetic effects. The extracts ofDodonaea viscosahave been reported to exert antidiabetic activity. However, the effective mediators and the underlying mechanisms were largely unknown. In this study, we investigated the action on PPARγtransactivation and adipocyte modulation of two typical flavonoid constituents fromD. viscosa, 5,4′-dihydroxy-7,8-dimethoxyflavanone and aliarin. Our results showed that 5,4′-dihydroxy-7,8-dimethoxyflavanone and aliarin were potential partial PPARγagonists. The compounds induced adipogenesis in 3T3-L1 cells, with an upregulated adiponectin mRNA level and enhanced insulin sensitivity. The favorable effects of 5,4′-dihydroxy-7,8-dimethoxyflavanone, aliarin, and other flavonoid constituents on adipocytes might contribute to the antidiabetic efficacy ofD. viscosa.