Diene-titanium complexes as synthetic intermediates for the construction of three- or five-membered carbocycles
Diene-titanium complexes as synthetic intermediates for the construction of three- or five-membered carbocycles
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DOI：
10.1021/ol702917c
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发表时间：
2008-03-06
期刊：
影响因子：
5.2
通讯作者：
Szymoniak, Jan
中科院分区：
文献类型：
--
作者：
Bertus, Philippe;Menant, Christine;Szymoniak, Jan
研究表明，二烯-钛配合物表现出与底物有关的1,2-或1,4-二碳离子反应性。在此基础上，分别用均烯丙基格氏试剂Ti(O-i-Pr)(4)和腈或氰酸酯制备了3-环戊胺和螺-乙烯基环丙烷内酰胺。
It has been shown that diene-titanium complexes exhibit substrate-dependent 1,2- or 1,4-dicarbanion reactivity. On this basis, 3-cyclopentenylamines and spiro-vinylcyclopropane lactams were easily prepared by using homoallylic Grignard reagents, Ti(O-i-Pr)(4), and nitriles or cyanoesters, respectively.