Comparison of creatinine and cystatin formulae with 51Chromium-ethylenediaminetetraacetic acid glomerular filtration rate in patients with decompensated cirrhosis
Comparison of creatinine and cystatin formulae with 51Chromium-ethylenediaminetetraacetic acid glomerular filtration rate in patients with decompensated cirrhosis
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DOI：
10.1111/jgh.13446
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发表时间：
2017-01-01
影响因子：
4.1
通讯作者：
Akriviadis, Evangelos
中科院分区：
文献类型：
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作者：
Cholongitas, Evangelos;Ioannidou, Maria;Akriviadis, Evangelos
背景与目的评价肾功能，即肾小球滤过率(GFR)已经变得非常重要，但传统的GFR数学公式对肝硬变患者的评价是不准确的。本研究的目的是比较稳定期失代偿期肝硬变患者基于血清肌酐(Scr)和血清胱抑素C(CysC)的GFR(EGFR)公式和(51)铬-乙二胺四乙酸GFR((51)Chr-GFR)。方法在129例高加索失代偿期肝硬化患者中，我们评估了基于SCR的GFRs[肾脏疾病和慢性肾脏疾病的饮食修改-流行病学(CKD-EPI)-SCR公式]，基于CysC的GFRs[Hoek，Larsson和CKD-EPI-CysC公式]，以及数学公式它结合了Scr和CysC[即CKD-EPI-SCR-CysC和Mindikoglu等人最近提出的针对肝硬变的特异性公式。(Mindikoglu-EGFR)[结果(51)Chr-GFR与各数学公式具有良好的相关性(Spearman r(2)>；0.68，P
Background and AimEvaluation of renal function, that is, glomerular filtration rate (GFR), has become very important, but conventional mathematical formulae for GFR assessment are inaccurate in patients with cirrhosis. The aim of the present study was to compare serum creatinine (sCr)-based and serum cystatin C (cysC)-based estimated GFR (eGFR) formulae with (51)Chromium-ethylenediaminetetraacetic acid GFR ((51)Chr-GFR) in patients with stable decompensated cirrhosis.MethodsIn 129 Caucasian patients with decompensated cirrhosis, we assessed sCr-based GFRs [Modification of Diet in Renal Disease and chronic kidney disease-epidemiology (CKD-EPI)-sCr formulae], cysC-based GFRs [Hoek, Larsson, and CKD-EPI-cysC equations], and the mathematical formulae, which combined both sCr and cysC [i.e. CKD-EPI-sCr-cysC and the specific for cirrhotics formula recently proposed by Mindikoglu et al. (Mindikoglu-eGFR)]. Multivariate linear regression analysis was used for GFR predictors in our cohort.ResultsThe correlations between (51)Chr-GFR and all mathematical formulae were good (Spearman r(2)>0.68, P