Interpretation of approximate entropy:: Analysis of intracranial pressure approximate entropy during acute intracranial hypertension
Interpretation of approximate entropy:: Analysis of intracranial pressure approximate entropy during acute intracranial hypertension
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DOI：
10.1109/tbme.2005.855722
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发表时间：
2005-10-01
影响因子：
4.6
通讯作者：
Goldstein, B
中科院分区：
文献类型：
--
作者：
Hornero, R;Aboy, M;Goldstein, B
我们研究了当受试者从正常的颅内压(~lt；20-25 mm Hg)到急剧升高的颅内压(定义为~lt；5m-in的颅内压“峰值”为25 mm Hg)时，颅内压信号的近似熵(ApEn)估计的颅内压复杂性的变化。我们假设，在颅内压急性升高期间，测量颅内压的复杂性和不规则性将会降低。为了验证这一假设，我们研究了患有严重创伤性脑损伤(TBI)的儿科受试者的颅内压峰值。我们的结论是，颅脑损伤后颅内压降低的复杂性与颅内高压(ICH)的发作相一致。这表明，在颅内压急剧上升期间，控制颅内压的复杂调节机制被破坏。此外，我们还进行了一系列实验，将近似熵用于分析不同特征的合成信号，目的是为了更好地理解近似熵本身，特别是它在生物医学信号分析中的解释。
We studied changes in intracranial pressure (ICP) complexity, estimated by the approximate entropy (ApEn) of the ICP signal, as subjects progressed from a state of normal ICP (< 20-25 mmHg) to acutely elevated ICP (an ICP "spike" defined as ICP > 25 mmHg for < 5 m-in). We hypothesized that the measures of intracranial pressure (ICP) complexity and irregularity would decrease during acute elevations in ICP. To test this hypothesis we studied ICP spikes in pediatric subjects with severe traumatic brain injury (TBI). We conclude that decreased complexity of ICP coincides with episodes of intracranial hypertension (ICH) in TBI. This suggests that the complex regulatory mechanisms that govern intracranial pressure are disrupted during acute rises in ICP. Furthermore, we carried out a series of experiments where ApEn was used to analyze synthetic signals of different characteristics with the objective of gaining a better understanding of ApEn itself, especially its interpretation in biomedical signal analysis.