Spatio-temporal concentration of acetylcholine in vertebrate synaptic cleft
Spatio-temporal concentration of acetylcholine in vertebrate synaptic cleft
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DOI：
10.1016/j.mcm.2006.03.003
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发表时间：
2006-11-01
影响因子：
--
通讯作者：
Ward, Kim
中科院分区：
文献类型：
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作者：
Aidoo, Anthony Y.;Ward, Kim
神经肌肉连接处（NMJ）突触间隙中乙酰胆碱（ACh）的浓度仍然无法通过基于时空分辨率的直接测量来量化。我们提出了突触间隙中乙酰胆碱浓度的模型。我们的模型考虑了释放机制和清除过程，以乙酰胆碱酯酶（AChE）的水解和通过间隙的扩散速率以及与烟碱乙酰胆碱受体通道的结合为代表。使用我们的模型，我们评估了这些因素的贡献和它们在确定神经肌肉连接处神经递质浓度的空间分布中的相对重要性。(c) 2006 Elsevier Ltd.版权所有。
The concentration of acetylcholine (ACh) in the synaptic cleft at the neuromuscular junction (NMJ) remains impossible to quantify using direct measurements based upon spatio-temporal resolution. We present a model of the concentration of ACh in the synaptic cleft. Our model considers the release mechanism and the clearance process, represented by the hydrolysis of acetylcholinesterase (AChE) and the rate of diffusion across the cleft and binding to nicotinic ACh receptor channels. Using our model, we evaluate the contribution of these factors and their relative importance in determining the spatial distribution of neurotransmitter concentration in the neuromuscular junction. (c) 2006 Elsevier Ltd. All rights reserved.