Increased activity and intranuclear expression of phospholipase D2 in human renal cancer
Increased activity and intranuclear expression of phospholipase D2 in human renal cancer
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DOI：
10.1006/bbrc.2000.3719
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发表时间：
2000-11-11
影响因子：
3.1
通讯作者：
Nozawa, Y
中科院分区：
文献类型：
--
作者：
Zhao, YT;Ehara, H;Nozawa, Y
We examined the PLD activities of human renal cancers and found that the PLD2 activity was greatly elevated in almost all cases examined as compared with the adjacent normal region. Western blot analysis showed the increased levels of PLD2 protein, but the PLD1 was not discernible. The oleate-dependent PLD activity was very low but appeared to increase in most cases. Interestingly, the immunohistochemical observations indicated the high expression of PLD2 in the nuclei of clear carcinoma cells. This is the first demonstration which suggests the possible involvement of PLDS in tumorigenesis of renal cancer. (C) 2000 Academic Press.
