Inactivation of the interoceptive insula disrupts drug craving and malaise induced by lithium
Inactivation of the interoceptive insula disrupts drug craving and malaise induced by lithium
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DOI：
10.1126/science.1145590
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发表时间：
2007-10-26
期刊：
影响因子：
56.9
通讯作者：
Torrealba, Fernando
中科院分区：
文献类型：
--
作者：
Contreras, Marco;Ceric, Francisco;Torrealba, Fernando
成瘾会深刻地改变动机回路，使得药物成为行为的强大强化物。内感受系统不断更新稳态和情绪信息，这些信息是动机决策的重要因素。我们检验了这样一种观点，即内感受信息在药物渴求以及不适的行为表现中是必不可少的。我们使有安非他明使用经验的大鼠的初级内感受皮层失活，这阻止了它们在位置偏好实验中寻求安非他明的冲动。内感受岛叶失活也减弱了急性锂给药所引起的不适症状。药物寻求和不适都会诱导岛叶中神经元激活的标志物Fos表达。我们得出结论，岛叶皮层是感知身体需求的关键结构，它为动机行为提供方向。
Addiction profoundly alters motivational circuits so that drugs become powerful reinforcers of behavior. The interoceptive system continuously updates homeostatic and emotional information that are important elements in motivational decisions. We tested the idea that interoceptive information is essential in drug craving and in the behavioral signs of malaise. We inactivated the primary interoceptive cortex in amphetamine-experienced rats, which prevented the urge to seek amphetamine in a place preference task. Interoceptive insula inactivation also blunted the signs of malaise induced by acute lithium administration. Drug-seeking and malaise both induced Fos expression, a marker of neuronal activation, in the insula. We conclude that the insular cortex is a key structure in the perception of bodily needs that provides direction to motivated behaviors.