Novel anterior-chamber angle measurements by high-definition optical coherence tomography using the Schwalbe line as the landmark
Novel anterior-chamber angle measurements by high-definition optical coherence tomography using the Schwalbe line as the landmark
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DOI：
10.1136/bjo.2010.189217
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发表时间：
2011-07-01
影响因子：
4.1
通讯作者：
Aung, Tin
中科院分区：
文献类型：
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作者：
Cheung, Carol Y.;Zheng, Ce;Aung, Tin
目的提出施瓦尔贝线（SL）作为新的解剖标志，独立于巩膜棘（SS）位置，用于高清光学相干断层扫描（HD-OCT）定量评估前房角（ACA）宽度。方法研究对象随机选择一只眼睛进行暗室前房角镜检查和HD-OCT。作者开发了一种计算机辅助程序，以定义两个新的定量参数来评估ACA宽度：在SL处测量的Schwalbe线角开口距离（SL-AOD）和距离SL 500 mm测量的Schwalbe线-小梁-虹膜间隙面积（SL-TISA）。结果73例（47例女性，26例男性）受试者，其中89%为中国人，均为男性，89%为女性。由于图像质量较差，作者排除了29张图像（19.9%），留下117张HD-OCT图像（65张鼻侧，52张颞侧）进行分析。SL和SS可分别在95%和85%的象限中识别（p=0.035）。SL-AOD和SL-TISA与SS参数（均r >= 0.85）和前房角镜分级（均r >= 0.69）显著相关。在闭角眼（n=36），SL参数显示出较强的相关性与房角镜分级（r范围为0.43至0.44）。结论新的角度参数，基于SL作为一个标志，可能是有用的量化ACA宽度和评估的风险关闭的角度。
Objective To propose the Schwalbe line (SL) as a new anatomical landmark, independent of the scleral spur (SS) location, for assessing anterior chamber angle (ACA) width quantitatively with high-definition optical coherence tomography (HD-OCT).Methods Study subjects underwent dark-room gonioscopy and HD-OCT in one randomly selected eye. The authors developed a computer-aided program to define two new quantitative parameters for assessing ACA width: Schwalbe line-angle opening distance (SL-AOD) measured at the SL, and Schwalbe line-trabecular-iris space area (SL-TISA) measured 500 mm from the SL. The associations between SL parameters, SS parameters and gonioscopic grading were evaluated.Results Seventy-three (47 females, 26 males) subjects were recruited, the majority of whom were Chinese (89%). The authors excluded 29 images (19.9%) owing to poor image quality, leaving 117 HD-OCT images (65 nasal, 52 temporal) for analysis. SL and SS could be identified in 95% and 85% of quadrants respectively (p=0.035). SL-AOD and SL-TISA were significantly correlated with SS parameters (all r >= 0.85) and gonioscopic grading (all r >= 0.69). In eyes with closed angles (n=36), SL parameters showed strong correlations with gonioscopic grading (r ranged from 0.43 to 0.44).Conclusions Novel angle parameters, based on SL as a landmark, may be useful to quantify ACA width and to assess for risk of angle closure.