Nail Psoriasis: A Systematic Evaluation in 313 Children with Psoriasis
Nail Psoriasis: A Systematic Evaluation in 313 Children with Psoriasis
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DOI：
10.1111/pde.13028
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发表时间：
2017-01-01
影响因子：
1.5
通讯作者：
Mahe, Emmanuel
中科院分区：
文献类型：
--
作者：
Pourchot, Diane;Bodemer, Christine;Mahe, Emmanuel
背景/目的：关于儿童牛皮癣患者指甲受累的患病率和临床方面的信息很少。本研究的目的是评估法国儿童牛皮癣的患病率和临床方面以及指甲受累的危险因素。方法：我们在23个法国皮肤病学中心进行了一项多中心横断面研究。在为期1年的研究中观察到的所有儿童都被系统纳入。收集指甲的临床特征。与临床方面的疾病和合并症的关系进行了评估。结果：313例牛皮癣患儿（平均年龄9.1±4.2岁，男孩149例，女孩164例）中，31.1%为家族性牛皮癣，30%为重度牛皮癣。平均发病年龄为6.1±3.7岁。32.3%的儿童有指甲。临床表现以指甲麻点（69.1%）、甲溶（40.0%）、足趾肿甲（27.5%）为主。所有手指受累的频率相似，而大脚趾受累的频率是其他手指的两倍（p < 0.005）。指甲受累与男性（p < 0.001）、掌跖银屑病（p < 0.001）、疾病严重程度（p = 0.003）和银屑病关节炎（p = 0.03）相关。结论：儿童银屑病患者指甲受累率为32.3%。报告了儿童的临床方面以及临床关联。与成人一样，甲牛皮癣与银屑病关节炎密切相关。
Background/Objectives: Little information is available on the prevalence and clinical aspects of nail involvement in children with psoriasis. The objective of this study was to evaluate the prevalence and clinical aspects of and the risk factors for nail involvement in French children with psoriasis.Methods: We performed a multicenter, cross-sectional study in 23 French dermatology centers. All children seen during the 1-year study were systematically included. Clinical features of the nails were collected. Association with clinical aspects of the disease and comorbidities were evaluated.Results: Of 313 children with psoriasis (mean age 9.1 +/- 4.2 yrs; 149 boys, 164 girls), 31.1% had familial psoriasis and 30% had severe psoriasis. The mean age at onset was 6.1 +/- 3.7 years. Nails were involved in 32.3% of children. The main clinical aspects were pitting (69.1%) for fingernails and onycholysis (40.0%) and pachyonychia (27.5%) for toenails. All of the fingers were involved at similar frequencies, whereas the big toe was involved twice as often as the others (p < 0.005). Nail involvement was associated with male sex (p < 0.001), palmoplantar psoriatic (p < 0.001), severity of disease (p = 0.003), and psoriatic arthritis (p = 0.03).Conclusion: The prevalence of nail involvement was 32.3% in children with psoriasis. Clinical aspects in children are reported, as well as clinical associations. As in adults, nail psoriasis is closely associated with psoriatic arthritis.