Brain activation during silent word generation evaluated with functional MRI
Brain activation during silent word generation evaluated with functional MRI
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DOI：
10.1006/brln.1998.1953
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发表时间：
1998-09-01
影响因子：
2.5
通讯作者：
Lewin, JS
中科院分区：
文献类型：
--
作者：
Friedman, L;Kenny, JT;Lewin, JS
这是一项关于功能性磁共振成像（fMRI）中单词生成的研究。11名正常健康的受试者被指示秘密地产生单词，（即，以特定的字母开头。图像采集在一个传统的1.5T扫描仪在三个连续的轴向平面，包括语言相关领域的颞叶和额叶。在将比例Talairach网格系统单独拟合到每个切片后，在Talairach框的水平上分析数据。感兴趣的主要变量是Talairach框内激活像素的数量。激活像素比例显著增加的盒子位于左侧新皮层的三个区域：（1）背外侧额叶皮层（布罗卡区）中的布罗德曼区44和45，（2）颞叶皮层中的21和37区，（3）和纹状体/外纹状体皮层（17和18区）。结果进行了讨论的认知模型的单词生成，并进行了详细的比较，与先前的相关成像研究的结果，（C）1998年学术出版社。
This is a study of word generation during functional MRI (fMRI). Eleven normal healthy subjects were instructed to generate words covertly, (i.e., silently) that began with particular letters. Images were acquired on a conventional 1.5T scanner at three contiguous axial planes encompassing language-related areas of the temporal and frontal lobe. The data were analyzed at the level of a Talairach box, after individually fitting the proportional Talairach grid system to each slice. The main variable of interest was the number of activated pixels within a Talairach box. Boxes with a significant increase in the proportion of activated pixels were located in three regions of the left neocortex: (1) Brodmann areas 44 and 45 in the dorsolateral frontal cortex (Broca's area), (2) areas 21 and 37 in the temporal cortex, (3) and the striate/extra-striate cortex (areas 17 & 18). The results are discussed in terms of a cognitive model of word generation and are compared, in detail, with the results of prior relevant imaging studies, (C) 1998 Academic Press.