Tumor necrosis factor alpha system in the bovine oviduct: a possible mechanism for embryo transport.
Tumor necrosis factor alpha system in the bovine oviduct: a possible mechanism for embryo transport.
复制标题
牛输卵管肿瘤坏死因子α系统：胚胎运输的可能机制。
DOI：
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发表时间：
2004
期刊：
影响因子：
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通讯作者：
A. Miyamoto
中科院分区：
文献类型：
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作者：
M. Wijayagunawardane;A. Miyamoto
输卵管的主动收缩模式发生在排卵期配子/胚胎的运动，这受到内分泌和旁分泌/自分泌因素的严格调控。本文就肿瘤坏死因子α(TNFpha)在奶牛输卵管收缩调节中的作用进行了综述。输卵管上皮细胞表达肿瘤坏死因子α配体及其受体，在卵泡期和排卵后高表达，在黄体期低表达，因此，奶牛输卵管中的肿瘤坏死因子α系统在排卵期最为活跃。在发情周期的围排卵期，免疫细胞大量存在于输卵管中，这些细胞也被认为是输卵管中肿瘤坏死因子α的另一个潜在来源。在体外模型中，肿瘤坏死因子α明显刺激局部收缩相关物质的产生和释放，如前列腺素(PGs)、内皮素-1(ET-1)和血管紧张素II(Ang II)。由于这些物质已被证明能在体外直接激活输卵管收缩，肿瘤坏死因子α似乎能刺激排卵期的输卵管收缩，并有助于创造一个适合配子/胚胎运输的最佳局部环境。此外，不能排除胚胎作为输卵管内肿瘤坏死因子α的来源的能力。为了支持这一观点，处于2-4细胞期的胚胎确实表达了TNFα，因此胚胎分泌的微量TNFα可能进一步局部作用于输卵管中PG、ET-1和Ang II的产生，从而可能导致胚胎周围微环境中输卵管的主动收缩。这可能会确保胚胎在最佳时间迁移到子宫内。
Active contractile pattern of the oviduct occurs during the periovulatory period for the movement of the gamete/embryo, which is strictly regulated by endocrine and paracrine/autocrine factors. In this review, an involvement of tumor necrosis factor alpha (TNFalpha) in the regulation of cow oviductal contraction is discussed. Oviductal epithelial cells express TNFalpha ligand and it's both receptor types; high expression during the follicular and postovulatory stages, while low expression during luteal stage and thus, TNFalpha system in the cow oviduct is most active during the periovulatory period. The immune cells present in large numbers in the oviduct during the periovulatory period of the estrus cycle, and these cells are also considered as another potential source for the TNFalpha in the oviduct. Using in vitro models, TNFalpha clearly stimulated local production and release of contraction related substances such as prostaglandins (PGs), endothelin-1 (ET-1) and angiotensin II (Ang II). Since these substances have been shown to activate directly the oviductal contraction in vitro, TNFalpha appears to stimulate the oviductal contraction during the periovulatory period and contribute to create an optimal local environment suitable for gamete/embryo transport. In addition, the ability of embryo to act as a source of TNFalpha in the oviduct cannot be excluded. To support this idea, the embryo at 2-4 cells stages indeed express TNFalpha, so that the minute quantities of TNFalpha secreted by the embryo may further acts locally to enhance the production of PG, ET-1 and Ang II in the oviduct, which may result in an active oviductal contraction in the microenvironment around the embryo. This may ensure the embryo to migrate into the uterus at the optimal time.