HIGH-RESOLUTION QUANTITATIVE RELAXATION AND DIFFUSION MRI OF 3 DIFFERENT EXPERIMENTAL BRAIN-TUMORS IN RAT
HIGH-RESOLUTION QUANTITATIVE RELAXATION AND DIFFUSION MRI OF 3 DIFFERENT EXPERIMENTAL BRAIN-TUMORS IN RAT
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DOI：
10.1002/mrm.1910340608
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发表时间：
1995-12-01
影响因子：
3.3
通讯作者：
HOEHNBERLAGE, M
中科院分区：
文献类型：
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作者：
EIS, M;ELS, T;HOEHNBERLAGE, M
放松时间T-1和T-2的定量参数图像的潜力，质子密度RHO和明显的扩散系数（ADC）表征三种不同的实验大鼠脑肿瘤（F98 Glioma，RN6 schwannoma和e376 Neuroblastoma）是在组织学确认的感兴趣区域（ROI）确定的所有参数值的研究中，水肿高于肿瘤中的所有参数值。转弯相对于正常大脑，ADC的ROI值和T-2的ROI值在肿瘤和水肿之间具有统计学意义（P <0.01）的分化。多维参数组合改善了不同组织之间的分化，但是，这三种肿瘤类型无法区分，所有参数图都允许鉴定整个肿瘤 - 充实区域，在T-2上，图像，水肿，可以识别出肿瘤，而肿瘤可以识别出肿瘤。在许多情况下，使用T-1的肿瘤表现几乎不可视化，地图与组织学相对应，但仍遭受肿瘤性不良的分化。
The potential of quantitative parameter images of the relaxation times T-1 and T-2, the proton density rho and the apparent diffusion coefficient (ADC) to characterize three different experimental rat brain tumors (F98 glioma, RN6 Schwannoma, and E376 neuroblastoma) was studied, All parameter values, as determined in histologically confirmed regions of interest (ROI), were higher in edema than in tumor, which in turn were elevated with respect to normal brain, ROI values of ADC and T-2 delivered statistically significant (P < 0.01) differentiation between tumor and edema. Multidimensional parameter combinations improved differentiation between different tissues, However, the three tumor types could not be differentiated, All parameter maps allowed the identification of the whole tumor-edema area, On T-2, images, edema could be identified best, whereas the tumor itself was hardly visualized, In many cases, tumor presentation using T-1, maps corresponded best with histology, nevertheless suffering from a poor tumor-edema differentiation.