The role of protein binding of trivalent arsenicals in arsenic carcinogenesis and toxicity
The role of protein binding of trivalent arsenicals in arsenic carcinogenesis and toxicity
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DOI：
10.1016/j.jinorgbio.2007.10.021
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发表时间：
2008-03-01
影响因子：
3.9
通讯作者：
Wallace, Kathleen
中科院分区：
文献类型：
--
作者：
Kitchin, Kirk T.;Wallace, Kathleen
砷致癌的三个最合理的生物学理论是蛋白质结合，氧化应激和DNA甲基化改变。本文综述了三价砷与蛋白质结合在砷致癌中的作用。利用真空过滤的受体解离结合技术，
Three of the most plausible biological theories of arsenic carcinogenesis are protein binding, oxidative stress and altered DNA methylation. This review presents the role of trivalent arsenicals binding to proteins in arsenic carcinogenesis. Using vacuum filtration based receptor dissociation binding techniques, the lifetimes of unidentate (