Low-Intensity Pulsed Ultrasound in Dentofacial Tissue Engineering
Low-Intensity Pulsed Ultrasound in Dentofacial Tissue Engineering
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DOI：
10.1007/s10439-015-1274-y
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发表时间：
2015-02
影响因子：
3.8
通讯作者：
E. Tanaka;S. Kuroda;Shinya Horiuchi;A. Tabata;T. El-Bialy
中科院分区：
文献类型：
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作者：
E. Tanaka;S. Kuroda;Shinya Horiuchi;A. Tabata;T. El-Bialy
口腔颌面部疾病影响着全世界数百万人，因此组织工程可以被认为是一种有趣的和临床相关的方法来再生受不同疾病影响的口腔颌面部组织。在组织再生的几项创新中，低强度脉冲超声（LIPUS）已广泛用于医学，作为治疗，手术和诊断工具。LIPUS被接受为促进骨折修复和再生。此外，LIPUS对软组织再生的影响也受到了广泛关注，许多研究都在评估LIPUS在组织工程软组织中的潜在应用。本文概述了LIPUS刺激作为一种用于增强再生/组织工程的工具的现状。本文共分五个部分。第一部分是对LIPUS的声学描述和机械作用的简要介绍。第二部分提出了牙颌面组织工程中存在的生物学问题。第三部分探讨了LIPUS对活体细胞和组织的生物学机制。在第四部分中，总结了LIPUS在牙科中对细胞代谢和组织再生的有效性。最后，第五部分介绍了LIPUS在临床上应用的可能性。目前的审查带来了更好地了解LIPUS治疗对口腔颌面部组织的生物效应，这是至关重要的成功整合的管理补救措施，组织再生/工程。为了开发一种基于证据的方法来使用LIPUS临床管理和治疗口面部退行性疾病，我们希望充分追求LIPUS生物治疗。尽管如此，这一相对较新的战略仍面临许多挑战，但利用这一战略取得的最新成就有望远远超出目前的可能性。
Oral and maxillofacial diseases affect millions of people worldwide and hence tissue engineering can be considered an interesting and clinically relevant approach to regenerate orofacial tissues after being affected by different diseases. Among several innovations for tissue regeneration, low-intensity pulsed ultrasound (LIPUS) has been used extensively in medicine as a therapeutic, operative, and diagnostic tool. LIPUS is accepted to promote bone fracture repair and regeneration. Furthermore, the effect of LIPUS on soft tissues regeneration has been paid much attention, and many studies have performed to evaluate the potential use of LIPUS to tissue engineering soft tissues. The present article provides an overview about the status of LIPUS stimulation as a tool to be used to enhance regeneration/tissue engineering. This review consists of five parts. Part 1 is a brief introduction of the acoustic description of LIPUS and mechanical action. In Part 2, biological problems in dentofacial tissue engineering are proposed. Part 3 explores biologic mechanisms of LIPUS to cells and tissues in living body. In Part 4, the effectiveness of LIPUS on cell metabolism and tissue regeneration in dentistry are summarized. Finally, Part 5 relates the possibility of clinical application of LIPUS in orthodontics. The present review brings out better understanding of the bioeffect of LIPUS therapy on orofacial tissues which is essential to the successful integration of management remedies for tissue regeneration/engineering. To develop an evidence-based approach to clinical management and treatment of orofacial degenerative diseases using LIPUS, we would like to be in full pursuit of LIPUS biotherapy. Still, there are many challenges for this relatively new strategy, but the up to date achievements using it promises to go far beyond the present possibilities.