Pax2 Is Expressed in a Subpopulation of Muller Cells in the Central Chick Retina
Pax2 Is Expressed in a Subpopulation of Muller Cells in the Central Chick Retina
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DOI：
10.1002/dvdy.22309
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发表时间：
2010-06-01
影响因子：
2.5
通讯作者：
Hallbook, Finn
中科院分区：
文献类型：
--
作者：
Boije, Henrik;Ring, Henrik;Hallbook, Finn
Muller cells in the chick retina are generally thought to be a homogeneous population. We show that the transcription factor Pax2 is expressed by Muller cells in the central chick retina and its expression was first observed at stage 32 (embryonic day [E] 7.5). Birth-dating indicated that the majority of Pax2-positive Muller cells are generated between stage 29 and 33 (E5.5-E8). At stage 42 (E16), several Muller cell markers, such as Sox2 and 2M6, had reached the peripheral retina, while the Pax2 labeling extended approximately half-way. A similar pattern was maintained in the 6-month-old chicken. Neither the Pax2-positive nor the Pax2-negative Muller cells could be specifically associated to proliferative responses in the retina induced by growth factors or N-methyl-D-aspartate. Pax2 was not detected in Muller cells in mouse, rat, guinea-pig, rabbit, or pig retinas; but the zebrafish retina displayed a similar pattern of central Pax2-expressing Muller cells. Developmental Dynamics 239:1858-1866, (C) 2010. 2010 Wiley-Liss, Inc.
