Polygenic prediction of the risk of perinatal depressive symptoms
Polygenic prediction of the risk of perinatal depressive symptoms
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DOI：
10.1002/da.23066
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发表时间：
2020-07-05
影响因子：
7.4
通讯作者：
Raikkonen, Katri
中科院分区：
文献类型：
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作者：
Rantalainen, Ville;Binder, Elisabeth B.;Raikkonen, Katri
背景围产期抑郁症对孕产妇健康和儿童发育有不良影响，但遗传基础尚不清楚。我们调查了围产期抑郁症状的多基因风险。方法对742例先兆子痫和宫内生长受限的孕妇进行产前14次和产后12个月内2次的基因分型，并完成流行病学研究中心抑郁量表。使用多峰阈值计算重度抑郁症、双相情感障碍、精神分裂症和交叉障碍的多基因风险评分。结果：重度抑郁症、精神分裂症和交叉障碍的多基因风险评分与产前和产后抑郁症状增加相关（多基因风险评分每增加一个标准差，增加0.8%-1%），但双相情感障碍与此无关。产前抑郁症状解释并介导了多基因风险评分与产后抑郁症状之间的关联（效应量比例介导：52.2%-88.0%）。此外，多基因风险评分与1.24-1.45倍的几率相关，属于在产前和产后期间表现出一贯高抑郁症状的群体，而不是一贯低抑郁症状的群体。结论非围产期人群中抑郁症、精神分裂症和交叉障碍的多基因风险评分可概括为围产期抑郁症状，并可用于识别妇女进行及时的预防干预。
Background Perinatal depression carries adverse effects on maternal health and child development, but genetic underpinnings remain unclear. We investigated the polygenic risk of perinatal depressive symptoms. Methods About 742 women from the prospective Prediction and Prevention of Pre-eclampsia and Intrauterine Growth Restriction cohort were genotyped and completed the Center for Epidemiologic Studies Depression scale 14 times during the prenatal period and twice up to 12 months postpartum. Polygenic risk scores for major depressive disorder, bipolar disorder, schizophrenia, and cross-disorder were calculated using multiplep-value thresholds. Results Polygenic risk scores for major depressive disorder, schizophrenia, and cross-disorder, but not bipolar disorder, were associated with higher prenatal and postpartum depressive symptoms (0.8%-1% increase per one standard deviation increase in polygenic risk scores). Prenatal depressive symptoms accounted for and mediated the associations between the polygenic risk scores and postpartum depressive symptoms (effect size proportions-mediated: 52.2%-88.0%). Further, the polygenic risk scores were associated with 1.24-1.45-fold odds to belong to the group displaying consistently high compared with consistently low depressive symptoms through out the prenatal and postpartum periods. Conclusions Polygenic risk scores for major depressive disorder, schizophrenia, and cross-disorder in non-perinatal populations generalize to perinatal depressive symptoms and may afford to identify women for timely preventive interventions.