Dendritic cells require T cells for functional maturation in vivo
Dendritic cells require T cells for functional maturation in vivo
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DOI：
10.1016/s1074-7613(00)80137-5
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发表时间：
1999-11-01
期刊：
影响因子：
32.4
通讯作者：
Flores-Romo, L
中科院分区：
文献类型：
--
作者：
Shreedhar, V;Moodycliffe, AM;Flores-Romo, L
我们检测了SCID和RAG 2（-/-）小鼠的树突状细胞（DC）状态，以评估体内T细胞对DC发育和功能的影响。这些小鼠的表皮和引流半抗原致敏皮肤的淋巴结中DC的数量减少。这些小鼠中的表皮DC在体内向来自正常小鼠的过继转移的半抗原致敏的T细胞呈递抗原方面存在缺陷。同样，引流淋巴结DC在体外和体内刺激幼稚T细胞的能力不足。DC数量以及在体内呈递抗原的能力受损，通过用正常T淋巴细胞重建这些动物来校正，表明T细胞对于正常DC在体内的成熟和功能至关重要。
We examined dendritic cell (DC) status in SCID and RAG2(-/-) mice-to assess the influence of T cells on DC development and function in vivo. These mice have reduced numbers of DC in the epidermis and lymph nodes draining hapten-sensitized skin. Epidermal DC in these mice were defective in presenting antigen in vivo to adoptively transferred, hapten-sensitized T cells from normal mice. Likewise, draining lymph node DC were deficient in their capacity to stimulate naive T cells in vitro and in vivo. DC numbers as well as the impaired ability to present antigen in vivo, were corrected by reconstituting these animals with normal T lymphocytes, suggesting that T cells are crucial for normal DC maturation and function in vivo.