Synthesis and reaction of potential alternate substrates and mechanism-based inhibitors of clavaminate synthase.
Synthesis and reaction of potential alternate substrates and mechanism-based inhibitors of clavaminate synthase.
复制标题
克拉维酸合酶的潜在替代底物和基于机制的抑制剂的合成和反应。
DOI：
10.1021/np50098a022
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发表时间：
1993
影响因子：
5.1
通讯作者：
Townsend,CA
中科院分区：
文献类型：
--
作者：
Iwata-Reuyl,D;Basak,A;Silverman,LS;Engle,CA;Townsend,CA
To elaborate the concept of weak interactions and their effect on Bergman Cyclization (BC), several 1,2‐dikynyl benzenes incorporating various combinations of donor and acceptor units in the two arms of the enediynes were designed and synthesized, and their charge‐transfer interactions followed by UV/Vis spectroscopy. The thermal reactivities, as studied by DSC, show an increase in reactivity for the donor/acceptor or donor/donor combinations relative to the acceptor/acceptor pair. Such an increase in reactivity can be explained on the basis of intramolecular charge transfer and π‐stacking interactions between the two arms, which may lower the distance between the two acetylenic ends. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)
