Nanoparticle transport in a realistic model of the tracheobronchial region
Nanoparticle transport in a realistic model of the tracheobronchial region
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DOI：
10.1002/cnm.1390
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发表时间：
2010-07-01
影响因子：
2.1
通讯作者：
Wall, W. A.
中科院分区：
文献类型：
--
作者：
Comerford, A.;Bauer, G.;Wall, W. A.
The transport and deposition of nanoparticles in the human lung has important health consequences for both hazardous and non-hazardous reasons. Example scenarios are inhalation of toxic pollutants from the surrounding environment and novel targeted drug delivery to the lung epithelial surface. In this paper, we develop a method to simulate the time-dependent transport of nanoparticles in CT-based models of the human tracheobronchial region. We consider the transport in a seven generation model based on an Euler Euler approach for particles ranging from 1.5 to 11 nm, i.e. in a range considered important for the tracheobronchial region. The results indicate that the deposition of smaller particles are affected more by the non-uniformity of the realistic geometry. In particular, we observe spatial variations in wall deposition directly resulting from the complex air flow patterns. Time-dependent effects tend to be less significant compared with the geometric effects. Copyright (C) 2010 John Wiley & Sons, Ltd.
