Transmembrane crosstalk between the extracellular matrix--cytoskeleton crosstalk.
Transmembrane crosstalk between the extracellular matrix--cytoskeleton crosstalk.
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发表时间：
2001
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影响因子：
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通讯作者：
B. Geiger;A. Bershadsky;R. Pankov;K. Yamada
中科院分区：
文献类型：
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作者：
B. Geiger;A. Bershadsky;R. Pankov;K. Yamada
整合素介导的细胞粘附在细胞外基质和细胞骨架之间提供了动态的双向连接。除了在细胞迁移和形态发生中发挥核心作用外，局灶黏附和相关结构还在细胞膜上传递信息，调节细胞外基质组装、细胞增殖、分化和死亡。本文综述了整合素的功能、机械传感器、分子开关和由粘附激活和整合的信号转导途径，统一的主题是局部物理力的重要性。
Integrin-mediated cell adhesions provide dynamic, bidirectional links between the extracellular matrix and the cytoskeleton. Besides having central roles in cell migration and morphogenesis, focal adhesions and related structures convey information across the cell membrane, to regulate extracellular-matrix assembly, cell proliferation, differentiation, and death. This review describes integrin functions, mechanosensors, molecular switches and signal-transduction pathways activated and integrated by adhesion, with a unifying theme being the importance of local physical forces.