TGF-β Controls the Formation of Kidney-Resident T Cells via Promoting Effector T Cell Extravasation.
TGF-β Controls the Formation of Kidney-Resident T Cells via Promoting Effector T Cell Extravasation.
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DOI：
10.4049/jimmunol.1601500
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发表时间：
2017-01-15
期刊：
影响因子：
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通讯作者：
Zhang N
中科院分区：
文献类型：
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作者：
Ma C;Mishra S;Demel EL;Liu Y;Zhang N
组织驻留记忆T细胞（TRM）是一类非循环记忆T细胞，是小鼠和人类免疫记忆的重要组成部分。虽然CD 69 + CD 103 + TRM细胞代表屏障组织（包括粘膜表面和皮肤）中的主要TRM细胞群，但CD 69 + CD 103 − TRM细胞在大多数非屏障组织（如肾脏）中占主导地位。转化生长因子-β（TGF-β）是屏障组织中CD 69 + CD 103 + TRM细胞分化所必需的。然而，非屏障组织中CD 69 + CD 103 − TRM细胞的发育控制在很大程度上仍然未知，TGF-β信号转导的参与也不太清楚。在这里，我们证明了TGF-β通过增强效应T细胞的组织进入来促进肾驻留T细胞的形成。在机制上，TGF-β增强E/P-选择素和炎性趋化因子介导的效应T细胞外渗。因此，TGF-β控制非屏障组织中TRM细胞分化的第一发育检查点。
Tissue-resident memory T (TRM) cells, a population of non-circulating memory T cells, are one of the essential components of immunological memory in both mouse and human. While CD69+CD103+ TRM cells represent a major TRM cell population in barrier tissues including the mucosal surface and the skin, CD69+CD103− TRM cells dominate most non-barrier tissues, such as the kidney. Transforming grow factor-β (TGF-β) is required for the differentiation of CD69+CD103+ TRM cells in barrier tissues. However, the developmental control of CD69+CD103− TRM cells in non-barrier tissues remains largely unknown and the involvement of TGF-β signaling is less clear. Here, we demonstrated that TGF-β promoted the formation of kidney-resident T cells via enhancing the tissue entry of effector T cells. Mechanistically, TGF-β enhanced E/P-selectin and inflammatory chemokine-mediated extravasation of effector T cells. Thus, TGF-β controls the first developmental checkpoint of TRM cell differentiation in non-barrier tissues.