Treatment Outcomes for Single Modality Management of Glomus Jugulare Tumors With Stereotactic Radiosurgery.
Treatment Outcomes for Single Modality Management of Glomus Jugulare Tumors With Stereotactic Radiosurgery.
复制标题
立体定向放射外科单一方式治疗颈静脉瘤的治疗结果。
DOI：
10.1097/mao.0000000000001160
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发表时间：
2016
期刊：
影响因子：
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通讯作者：
Bush,MatthewL
中科院分区：
文献类型：
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作者：
Dobberpuhl,MitchellR;Maxwell,Stevie;Feddock,Jonathan;StClair,William;Bush,MatthewL
目的：目的是评估仅接受单次伽玛刀放射外科治疗的颈静脉球肿瘤患者的听力学结果、症状反应和肿瘤体积反应。研究设计：单一机构回顾性审查。地点：学术、三级转诊中心。患者：使用颈静脉球诊断代码来识别患者。仅包括接受伽玛刀放射外科手术的患者。那些以前接受过任何方式治疗的人被排除在外。总共纳入 12 例患者的肿瘤反应和症状反应数据，其中 7 例纳入听力测定分析。 主要指标：最近一次随访时的听力测定数据与就诊情况的比较、搏动性耳鸣的主观改善以及最近一次随访时与治疗前相比肿瘤体积的变化。 结果：最近一次随访的平均时间为 27.6 个月。纯音平均值或单词识别没有显着变化。 80% 的患者的搏动性耳鸣完全消失或改善。颅神经病变稳定或改善。一名患者在治疗 2 年后出现面神经麻痹，通过类固醇治疗缓解。肿瘤控制率为100%，肿瘤体积平均变化减少37%。结论：单一模式伽玛刀放射外科治疗颈静脉球肿瘤似乎是安全的。大多数患者的治疗结果是肿瘤体积缩小并改善搏动性耳鸣。治疗后听力损失没有明显进展。所有患者的下颅神经功能均保持稳定。
Objectives:The objectives were to evaluate the audiological outcomes, response of symptoms, and response of tumor volume in patients with glomus jugulare tumors treated solely with single fraction gamma knife radiosurgery.Study Design:Single institution retrospective review.Setting:Academic, tertiary referral center.Patients:The diagnosis code for glomus jugulare was used to identify patients. Only those who underwent gamma knife radiosurgery were included. Those previously treated with any modality were excluded. A total of 12 patients were included for the tumor response and symptom response data and 7 of those were included in the audiometric analysis.Main Outcomes Measures:Audiometric data at most recent follow-up compared with presentation, subjective improvement in pulsatile tinnitus, and change in tumor volume at most recent follow-up compared with pretreatment.Results:The average time to most recent follow-up was 27.6 months. There was no significant change in pure-tone average or word recognition. Pulsatile tinnitus completely resolved or improved in 80% of patients. Cranial neuropathies were stable or improved. A single patient experienced facial nerve paresis 2 years after treatment, which resolved with steroid treatment. Tumor control was 100% and the average change in tumor volume was a decrease of 37%.Conclusion:Single modality gamma knife radiosurgery treatment of glomus jugulare tumors seems to be safe. Treatment results in decreased tumor volume and improved pulsatile tinnitus in most patients. There was no significant progression of hearing loss after treatment. Lower cranial nerve function remains stable in all patients.